DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha4 and acr-14

DIOPT Version :9

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_495716.1 Gene:acr-14 / 191601 WormBaseID:WBGene00000053 Length:500 Species:Caenorhabditis elegans


Alignment Length:530 Identity:172/530 - (32%)
Similarity:283/530 - (53%) Gaps:79/530 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 VAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYD 70
            |.|:.|..||...|..||:...|||.|::..|.|.::..|:|::||:.|||:|:...:::..|.|
 Worm    15 VKGSVDEYRLLQYLKENYDSFERPVENSSAPLDVKVRFLLNQIMDVDEKNQVMSILAYMDYHWND 79

  Fly    71 YKLRWEPKEYGGVHMLHVPSD-----HIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPA 130
            |||.|:||.:||:..:....|     .:||||::|:|:...:|:.|.:::..:.|.|.|:..||.
 Worm    80 YKLTWDPKLFGGIRDVRFSGDDDASFKLWRPDVLLFNSVSESFDSTYSSRFIVSSNGDVQQNPPG 144

  Fly   131 IYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHM---------------DEQQGSN---- 176
            |::..|:|||.|:|||:|||.||.|||||:|..::|..:               .|:..:|    
 Worm   145 IFRFVCQIDVTYYPFDKQTCFLKLGSWTYNGQYINLDFLLTQIIGLHGIPIVVEPERSSTNYASY 209

  Fly   177 VVAVGVDLSEFYMSVEWDILEVPAVR-NEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMG 240
            .|...:||..:..:.|||:...|..| .:||.|  || |.::.|.|.:||:||.|.:|:|||.:.
 Worm   210 FVNESIDLQVYLQNGEWDLEGTPGKRVVQKFGT--DE-YHELYFYIHIRRRTLAYGINLIIPSLV 271

  Fly   241 ISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISI 305
            ||.:|:|.|.||.|:.||:||..::|:|:..|..:|....||.|..||:|..:....::||:.|.
 Worm   272 ISMMTILGFTLPPDACEKITLETTVLLSVIFFLQMVSSTSPPQSQSVPILAAFFSCCLMLVACSC 336

  Fly   306 CVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSAT 370
            ..||:.|::|.|.|:||:|:|.::::|||:||..|.:.:|.:.......:|..:.|   |.:..:
 Worm   337 VFTVLTLSLHHRKPETHEMSPTMRKIFIDWLPYILCMCKPDHPKTPKPKVLGKSIA---PIHRLS 398

  Fly   371 NIDRLVSSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAA---VPDMDIGPLG 432
            .|..|       :||:  :||:...:    .:..|:..||.:.. ::..|.|   :.:.||    
 Worm   399 TIPML-------NLPR--VSQTTFPD----KNVFVYHEVPAVIK-NTSRICAELLIIERDI---- 445

  Fly   433 MKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLA 497
                         .|.|.||.          |.||  ||  .::.:|::.||.:|||.|::|:..
 Worm   446 -------------EKMLDKIE----------EDTK--ED--MLRSEWRFAAMAVDRLCLYVFSAF 483

  Fly   498 VVVGTAGIIL 507
            :.:.|.|:|:
 Worm   484 ITMITCGLIV 493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:273305 170/526 (32%)
Neur_chan_LBD 12..227 CDD:280998 84/239 (35%)
Neur_chan_memb 234..505 CDD:280999 79/273 (29%)
acr-14NP_495716.1 LIC 21..483 CDD:273305 166/512 (32%)
Neur_chan_LBD 21..258 CDD:280998 84/239 (35%)
Neur_chan_memb 265..491 CDD:280999 79/273 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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