Protein Alignment nAChRalpha4 and acr-11

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_491906.1
• Gene: acr-11 / 191599
• WormBaseID: WBGene00000050
• Length: 461
• Species: Caenorhabditis elegans
• Alignment Length: 513
• Identity: 183/513 - (35%)
• Similarity: 290/513 - (56%)
• Gaps: 72/513 - (14%)

  Fly     1 MVHGAVA-GNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWV 64
            ::|..:. |:....:|:.|||..||.|.|||.|::..|:|.|||.|.|::||:.||||::.|.|:
 Worm    14 IIHSNLCDGSVAETKLFTDLLKGYNPLERPVQNSSQPLEVKIKLFLQQILDVDEKNQIVSVNAWL 78

  Fly    65 EQSWYDYKLRWEPKEYGGVHMLHVP--SDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWK 127
            ..:|:|:||:||||:|||:..:..|  |||||:||::|||:|..:|:.|..:....|..|.|.|.
 Worm    79 SYTWFDHKLQWEPKKYGGIQDIRFPGSSDHIWKPDVLLYNSAAEDFDSTFKSNLLTYHTGTVVWI 143

  Fly   128 PPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVE 192
            ||.:.|..|::||.:||||:|.|.:||||||:.|:.:||:..|:..|:.    .:|||.:.::.|
 Worm   144 PPGVLKFVCQLDVTWFPFDDQVCEMKFGSWTFHGYAIDLQIDDDTNGTQ----SMDLSTYLVNGE 204

  Fly   193 WDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGE 257
            |.::...|.|...:|.||.|||..:.:.:.:||:||:|..|:|||.:.||.:.:|.|..|.|:||
 Worm   205 WQVISTNAKRVVSYYKCCPEPYPTVNYYLHIRRRTLYYGFNLIIPSLLISLMAILGFMFPPDAGE 269

  Fly   258 KVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTH 322
            |:||.::||:::..|..:|.|:.||||..|||:|.:....|::||.|:..|:||||:||||..:|
 Worm   270 KITLEVTILLAIVFFLSMVSEMTPPTSEAVPLIGVFFSCCMLVVSASVVFTIVVLNLHFRSADSH 334

  Fly   323 KMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKE 387
            :|.|.|:||.::|||..||:.||.|.|..:.::              .:.|::...      ||.
 Worm   335 EMNPLVRRVLLEFLPWLLFMSRPGYKFVKANVI--------------DSTDKMPKK------PKN 379

  Fly   388 DLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKI 452
            .|..::.:|                 |.                |.::.||         .|..:
 Worm   380 PLDCNLPSN-----------------HA----------------GYEAQIL---------LLHSV 402

  Fly   453 HKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAP 510
            |..  ..|.:|.:.|.:.|. :::.||::.|||:||..|.:||:.:|:....|::.||
 Worm   403 HTE--LRRVVAFYNKEEHDE-RIQTDWRFAAMVVDRACLLLFTVFIVISILAIMMSAP 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	180/506 (36%)
		Neur_chan_LBD	12..227	CDD:280998	93/216 (43%)
		Neur_chan_memb	234..505	CDD:280999	81/270 (30%)
acr-11	NP_491906.1	LIC	25..456	CDD:273305	179/499 (36%)
		Neur_chan_LBD	26..239	CDD:280998	93/216 (43%)
		Neur_chan_memb	246..447	CDD:280999	80/265 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910