Protein Alignment nAChRalpha4 and acr-9

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_510285.2
• Gene: acr-9 / 191597
• WormBaseID: WBGene00000048
• Length: 534
• Species: Caenorhabditis elegans
• Alignment Length: 551
• Identity: 193/551 - (35%)
• Similarity: 295/551 - (53%)
• Gaps: 84/551 - (15%)

  Fly     6 VAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYD 70
            |..:.|..||..||..||:...|||.|.::.|.|.:|:.|.|::||:.|||::|...|:|..|.|
 Worm    22 VHSSADEYRLLADLRHNYDPYERPVANASEPLVVSVKIYLQQILDVDEKNQVITLVAWIEYQWTD 86

  Fly    71 YKLRWEPKEYGGVHMLHVP--SDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYK 133
            |||:|:|.||||:..:.:|  ::.||:||::|||:||.||:.|......:...|.|...||.|.|
 Worm    87 YKLKWDPSEYGGIKDIRIPGNANAIWKPDVLLYNSADENFDSTYPVNYVVSYTGDVLQVPPGILK 151

  Fly   134 SSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEV 198
            .||:||:.|||||:|.|.||||||||.|..:||| ::..:|.|:...|:|:..:..:.||::|.|
 Worm   152 LSCKIDITYFPFDDQICHLKFGSWTYSGNFIDLR-INGPEGKNISDEGIDVQYYVQNGEWNLLAV 215

  Fly   199 PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSI 263
            ||......:.  ::||..:.|.:.::|:||:|.:|:|||...||.:|||.|.||.|:|||:||.|
 Worm   216 PARHETNIFD--EQPYPSLFFYLIIQRRTLYYGLNLIIPSFLISLMTVLGFTLPPDAGEKITLEI 278

  Fly   264 SILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWV 328
            :||:|:..|..:|.::.||||..|||:|.:....|::||.|:..||:|||:|.|.|:||:|:|::
 Worm   279 TILLSVCFFLSMVADMTPPTSEAVPLIGAFFSCCMLVVSASVVFTVLVLNLHNRKPETHEMSPFL 343

  Fly   329 KRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSG-YNNSL-------- 384
            :.:.:.:||..|.::||      .|.:...||      ..|...:.....| ..|.:
 Worm   344 RELLLIWLPWLLLMRRP------GKTIFNCTH------LKAEKAEEKAKQGSIKNGVGPGKPTDS 396

  Fly   385 --PKEDLS----------QSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPI 437
              |.|.||          |:|.....|              |...:.:     |.:.|..|
 Worm   397 VHPSEGLSLMKNIKLGRQQTIDFEYEF--------------HVQHNHL-----MPVAPSEM---- 438

  Fly   438 LNNPAFSHSKCLPK--------------IHKSCFCVRFIAEHT-----KMQED--STKVKEDWKY 481
              .|..::||.:.:              :.|:|..::.|:..|     ||:||  ..:...|||:
 Worm   439 --TPRVTYSKVMAESYVEDVVMTELNKYMQKACLELKNISSQTRAMRKKMEEDERDEQAANDWKF 501

  Fly   482 VAMVLDRLFLWIFTLAVVVGTAGIILQAPTL 512
            .|||:||..|..|::.:||.|.||:..:|.|
 Worm   502 AAMVVDRCCLITFSVFIVVSTCGIMFSSPHL 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	189/542 (35%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	92/219 (42%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
acr-9	NP_510285.2	LIC	28..525	CDD:455710	187/536 (35%)
		Neur_chan_LBD	28..242	CDD:460752	90/216 (42%)