Protein Alignment nAChRalpha4 and acr-5

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001367477.1
• Gene: acr-5 / 191596
• WormBaseID: WBGene00000044
• Length: 598
• Species: Caenorhabditis elegans
• Alignment Length: 539
• Identity: 137/539 - (25%)
• Similarity: 234/539 - (43%)
• Gaps: 112/539 - (20%)

  Fly    11 DAKRLYDDLL--SNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKL 73
            |.:||.::||  :.|.|.|.|..:.|...:|.:.:.|.|::||:...|.:..|:|:.|.|||..|
 Worm   103 DQRRLVEELLDPNYYEKTVHPKRDYTRPTRVNLSMSLYQILDVDEHMQSIEVNVWMVQHWYDEFL 167

  Fly    74 RWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLV-------EWKP--- 128
            .|.|.:||.::...||...||.||..|||:.:      |..|.|   |.|:       .|..
 Worm   168 DWNPVDYGMINRTIVPYHQIWIPDTYLYNSEE------LEQKKT---ESLMNAQLETGHWNQKKD 223

  Fly   129 --------PAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLS 185
                    |||||.||.:||.:||:|.|.|.....|||:|...:|...:...         |:|.
 Worm   224 GAKVQLMFPAIYKLSCRMDVRWFPYDRQNCTFIISSWTHDKQTIDYWPLSST---------VNLG 279

  Fly   186 EFYMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFY 250
            ....:.||:::....||.|:.:.||..|::.:..::.:|||.|:|.:|:::|...|:.:.|..|:
 Worm   280 NMARNDEWEVISFEFVRVEETFKCCTAPWVMLYAHLVIRRKPLYYMINLVVPTSIITIVAVTGFF 344

  Fly   251 LPSDSG----EKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVV 311
            .|:.|.    ||:.|.|:.|:::.|..|:|...:|.||..|||:..|.|..::::.:...:...|
 Worm   345 TPTSSSSERDEKLYLGINTLLTMSVMMLMVCNQMPSTSTYVPLMSWYYIGIIMVIVVGTFLATGV 409

  Fly   312 LNVHFRSPQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLV 376
            |.:|.:......::..::::..:.:..|..:..|     ||.:.|............:|::|.|:
 Worm   410 LAIHGQKHYNKPISDRIRKLIYNPVVEFFILSPP-----TSLIDLWTEFGVISEQRHSTHLDPLL 469

  Fly   377 SSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNP 441
            ..                           |  :.|::|.:    .|.|....|.:..:...|.:
 Worm   470 LQ---------------------------H--MDPISHTT----RADPQHFFGSISSQMCDLQS- 500

  Fly   442 AFSHSKCLPKIHKSCFCVRFIAEHTKM----------------------QEDSTKVKEDWKYVAM 484
            .:|::..|..|      .|...:|.||                      |:...:...:|:::|.
 Worm   501 TYSYTARLATI------TRQYTQHAKMKALRKNQYRMSMDTSQARGVKKQKMQRRCSLEWEFLAN 559

  Fly   485 VLDRLFLWI---FTLAVVV 500
            ||||:.|.|   ||.||.:
 Worm   560 VLDRILLTIFCGFTFAVFI 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	137/539 (25%)
		Neur_chan_LBD	12..227	CDD:280998	72/234 (31%)
		Neur_chan_memb	234..505	CDD:280999	60/296 (20%)
acr-5	NP_001367477.1	LIC	104..581	CDD:273305	136/538 (25%)
		Neur_chan_LBD	104..321	CDD:397192	72/234 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910