DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha4 and acr-6

DIOPT Version :9

Sequence 1:	NP_001097669.2	Gene:	nAChRalpha4 / 40521	FlyBaseID:	FBgn0266347	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_491354.2	Gene:	acr-6 / 191479	WormBaseID:	WBGene00000045	Length:	551	Species:	Caenorhabditis elegans

Alignment Length:	539	Identity:	198/539 - (36%)
Similarity:	307/539 - (56%)	Gaps:	44/539 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEP 77
            |.|::.||:.|||:..|.....:.|.:..||:|.|::||:.|:|::|....:...|.||:|.|.|
Worm    21 KSLFETLLARYNKIAFPSGEFNNTLTIEFKLRLDQIVDVHEKDQVITLKGTLIHHWLDYRLSWNP 85

  Fly    78 KEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEY 142
            .|:|.:.::|.|.:.:|.|||:|||||.|:..|:..|:..:..||.|.|:||.:|.:.|.||:|:
Worm    86 DEFGNITLMHFPGEMLWLPDIILYNNAHGSPWVSETTQVHVSFEGRVTWQPPVVYDAFCNIDIEW 150

  Fly   143 FPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQ--------GSNV--VAVGVDLSEFYMSVEWDILE 197
            :|:|.|.|.||||||||.|.:::|.|:...|        |.||  |..|||||.:..|||||:|.
Worm   151 YPYDLQICELKFGSWTYGGSQLNLIHLTTDQANESTDATGDNVWKVERGVDLSNYQESVEWDLLS 215

  Fly   198 VPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLS 262
            |..:|::|:|.|||.|.:|||:.:.:|||.||||||:||||:.::.:|:..||||.:|.:|:.|.
Worm   216 VEGIRHKKWYPCCDYPSIDITYYLHIRRKKLFYTVNMIIPCVCLASMTLWVFYLPCESHQKIQLC 280

  Fly   263 ISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPW 327
            ||:|::|.::||::::||||||:|.||:.|||.|.||:|::|:..||.:.|:|:|: ....|..:
Worm   281 ISVLVALTLYFLMLIDIIPPTSIVTPLILKYLSFTMIMVALSVTCTVFIQNIHYRA-YYQPMPRF 344

  Fly   328 VKRVFIDFLPAFLFIKRPT----YN-----------FETSKLLLKDTHACFYPYYSATNIDRLVS 377
            ||..||:.|...|.|.|.|    |:           .....:|.|......:....||...:.|:
Worm   345 VKHWFIEKLGKKLLISRKTEQAQYHRTAQHVKQVNALSAMNILEKQFQKTLFELEIATMAKKTVT 409

  Fly   378 SGYN--NS----LPKEDLSQSITANGPFGGSCQVHGPVPPLTHCS-SDEIAAVPDMDIGPLGMKS 435
            :...  ||    ||..:.|.|:....|  ....|...:..|.... :|:|......:|.|...|.
Worm   410 AAPKTVNSIFLELPMMNRSVSVKIRKP--SVKAVKNRMRRLLSIDMTDDIRGKETEEISPETTKD 472

  Fly   436 PILNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVV 500
               .:|   ..:.|.|..|:   :.|||:....:..:.:.:.||::|::|:||:.|.||:..:.:
Worm   473 ---TDP---DREKLRKAEKN---IHFIAKTLTDERRAQEAEADWQFVSLVIDRMLLIIFSFTITI 528

  Fly   501 GTAGIILQAPTLYDDRIPI 519
            ||...|..|||:.|:|.||
Worm   529 GTILTIFSAPTMRDNREPI 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	190/523 (36%)
		Neur_chan_LBD	12..227	CDD:280998	95/223 (43%)
		Neur_chan_memb	234..505	CDD:280999	88/292 (30%)
acr-6	NP_491354.2	Neur_chan_LBD	23..244	CDD:280998	93/220 (42%)
acr-6	NP_491354.2	Neur_chan_memb	252..524	CDD:280999	86/283 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920