DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha4 and lgc-19

DIOPT Version :9

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_502905.2 Gene:lgc-19 / 190895 WormBaseID:WBGene00013655 Length:400 Species:Caenorhabditis elegans


Alignment Length:366 Identity:79/366 - (21%)
Similarity:155/366 - (42%) Gaps:74/366 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 KRLYDDLLSNYNKLVRPVVNTTDV-------------LKVCIKLKLSQLIDVNLKNQIMTTNLWV 64
            :.|...:..:|:..|.||....||             ....|.|...:|::|....:.::..:.:
 Worm    35 RNLTKHIFRDYDPTVSPVYTWVDVDLPIGYDNEAPKRYNYTIFLYYLKLVEVQEPQEKISVVMEI 99

  Fly    65 EQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRP--------DIVLYNNADGNFEVTLATKATIYSE 121
            .:.|||.:|.|....:....|:::..|.:|.|        |||.:.:.|...       ..|.:.
 Worm   100 MEYWYDARLSWNASAWQNTTMIYMKQDKVWSPTISVFGVNDIVDFRDNDNRL-------ICIENT 157

  Fly   122 GLVEWKPPAI-YKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLS 185
            |.: |...:: ..::||:||..||||.|.|.::|....:...:||:                 |:
 Worm   158 GFI-WDYVSVRVSANCEMDVSRFPFDTQICQIRFCLPIFYRVQVDI-----------------LN 204

  Fly   186 EFYMSV------------EWDILEV-----PAVRNEKFYTCCDEPYLDIT-FNITMRRKTLFYTV 232
            |.|..:            ||.:|.:     ..|.|:...|      :|:. |.||:||..|:|..
 Worm   205 EIYEEIMDERIFKTMGNSEWKLLNLTNRVEALVYNDNMGT------MDLAIFEITIRRNPLYYIY 263

  Fly   233 NIIIPCMGISFLTVLTFYL-PSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIF 296
            .|:.|...|:|::::..:| .:|...::.:.::.::::.....::.:.||.|. .:||||.|:|.
 Worm   264 MIVFPSFIINFVSIVGVFLNGADKMSRLNVGLTNIMTMTFILGVMADKIPRTG-NIPLLGIYIII 327

  Fly   297 AMILVSISICVTVVVLNVH-FRSPQTHKMAPWVKRVFIDFL 336
            .::::.|:|.:...:..:. :.||:..|....::.....||
 Worm   328 NLVIMLIAIAIVTAITELRKWASPKLRKKKTALRAQLESFL 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:273305 79/366 (22%)
Neur_chan_LBD 12..227 CDD:280998 55/253 (22%)
Neur_chan_memb 234..505 CDD:280999 22/105 (21%)
lgc-19NP_502905.2 LGIC_ECD_cation 75..257 CDD:349790 47/212 (22%)
LGIC_TM_cation 259..>346 CDD:349853 19/87 (22%)
TM1 helix 263..284 CDD:349853 5/20 (25%)
TM2 helix 292..313 CDD:349853 0/20 (0%)
TM3 helix 323..346 CDD:349853 4/22 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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