Protein Alignment nAChRalpha4 and acr-24

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001255865.1
• Gene: acr-24 / 190686
• WormBaseID: WBGene00013534
• Length: 578
• Species: Caenorhabditis elegans
• Alignment Length: 604
• Identity: 155/604 - (25%)
• Similarity: 255/604 - (42%)
• Gaps: 142/604 - (23%)

  Fly     2 VHGAVAGNPDAK-----------RLYDDLLS--NYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNL 53
            :.|||.|..:|.           ||..||..  .|:..||||:|.:....|...:.|.|::.:|.
 Worm    11 IMGAVFGAREALMDDYGEFLPHIRLAKDLTDPRRYDSRVRPVMNHSKPTTVSFSMSLYQILSINE 75

  Fly    54 KNQIMTTNLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVT----LAT 114
            |.|.:..|:|..|.|.|..|.|.|..||.::...:|.|.||.||..|||:...|.|.|    ...
 Worm    76 KQQNVDLNVWAIQKWNDDFLGWNPYLYGMINTTILPFDAIWLPDTYLYNSVVMNREETERYINVV 140

  Fly   115 KATIYSEG----LVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGS 175
            ..|.|.:|    .|::..||:|::||.:|:.:||:|:|.|.|...|||  ..|.|:.:..|.:
 Worm   141 VTTNYWKGETGAEVKFMYPALYRTSCLLDIRFFPYDQQACKLTISSWT--SSKSDINYEPEHE-- 201

  Fly   176 NVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMG 240
                 .|::..|..:.||.::.....|.|:.:.||.||::.:...:.:|||.|:|.||::||...
 Worm   202 -----SVNMDNFLPNEEWVVVSFNIKRVEEKFVCCPEPWVLLEAVLVVRRKPLYYIVNLVIPTSV 261

  Fly   241 ISFLTVLTFY----LPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILV 301
            |:.:.|..|:    ..|:..||::|.|..|:::.:..::|.|.:|.:|..|||.|.:.:..:.::
 Worm   262 ITLVAVTGFFTAASTSSERREKLSLGIDSLLAMSILMMMVSEQMPTSSDFVPLFGIFYLSIIFII 326

  Fly   302 SISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPY 366
            .|....|..:||||.:......::|.|..:|...:..:|.::.||...|    |..:|...|
 Worm   327 FIGTLFTAFILNVHLQKMYAKPVSPIVSYIFFGRIAQWLRMRPPTMLLE----LWNETGVTF--- 384

  Fly   367 YSATNIDRLVSSGYNNS---------LPKEDLSQS---ITANGPFGGSCQVHGPVPPLTHCSSDE 419
                     ...|..||         :||...|.|   :..:....|...:..|:...::.|.|:
 Worm   385 ---------GKEGQKNSKTIPKNHKMIPKVTSSSSGLHLLKSNSGSGRAPLAAPISARSYISMDD 440

  Fly   420 I-----------------------------------------------AAVPDMDIGPLGMKSPI 437
            :                                               .:||..:.|||.:.:..
 Worm   441 MKREAARRNWRRLVAKINSNKQNGVKIVGGGERGQLRQANRKKMAPSAISVPHGEPGPLMLSASA 505

  Fly   438 LNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDST----KVKE----DWKYVAMVLDRLFLWIF 494
            ::  |||                       :..|||    |:|.    :|:|:|.||||:.|.:|
 Worm   506 IS--AFS-----------------------VTGDSTILESKLKRRYALEWEYLASVLDRVLLIVF 545

  Fly   495 TLAVVVGTAGIILQAPTLY 513
            :|.|...|:.:||....::
 Worm   546 SLVVFAVTSIMILDLKIIH 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	153/594 (26%)
		Neur_chan_LBD	12..227	CDD:280998	73/235 (31%)
		Neur_chan_memb	234..505	CDD:280999	71/341 (21%)
acr-24	NP_001255865.1	Neur_chan_LBD	34..248	CDD:280998	72/222 (32%)
		Neur_chan_memb	255..>411	CDD:280999	41/171 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010