Protein Alignment nAChRalpha4 and pbo-5

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001024240.1
• Gene: pbo-5 / 189903
• WormBaseID: WBGene00012857
• Length: 509
• Species: Caenorhabditis elegans
• Alignment Length: 510
• Identity: 123/510 - (24%)
• Similarity: 224/510 - (43%)
• Gaps: 91/510 - (17%)

  Fly    12 AKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWE 76
            :|||.:.|||.:|....|    ..:|.|..:|:|..::.::...|.||..::|::.|.|..|.|:
 Worm    67 SKRLTEYLLSRHNLNAPP----DGLLYVEYELELVHILGIDELKQTMTVLIYVDEHWVDPSLTWD 127

  Fly    77 PKEYGGVHMLHVPSDHIWRPDIVLYNNADGN---FEVTLA---TKATIYSEGLVEWKPPAIYKSS 135
            |..:||:....:|.|.||.|||:::|....|   .|..|:   ..|.|:..|.:....||::..|
 Worm   128 PALFGGITKTWIPLDKIWVPDIIVFNMVKSNRLAHEDLLSAVRAPARIHYNGTIVASHPAVHTVS 192

  Fly   136 CEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLR-HMDEQQGSNVVAVGVDLSEFYMSVEWDILEVP 199
            |||::.:||.|:|.|.::..||.|...|:.|. |.|.           .|..:..:.||.:|.:.
 Worm   193 CEINIRHFPLDDQRCAIEIASWAYGQEKIRLHAHTDH-----------SLEHYKRNEEWHLLNLN 246

  Fly   200 AVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVL----TFYLPSDSGEKVT 260
            .  :|:.|........::.|.|:::|:.|||.|.:..|...:..::|:    .|....:..|:.|
 Worm   247 V--SEEKYEHEGVEVSEVKFEISLKRRPLFYMVTLTFPSYIMCAISVVGLFARFSTTGEREERFT 309

  Fly   261 LSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMA 325
            |.::.::::.|..|:|.|.:|.:|..||||..|.:|.|::|||:...|.:|:.||.......:.:
 Worm   310 LGVTAILTMAVLSLVVSEKVPHSSTHVPLLVAYFLFNMVIVSIAAMTTGIVMKVHRLGRYGDEPS 374

  Fly   326 PWVKRVFIDFLPAFLFIKRPTYNF---ETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKE 387
            .:..|.|: ..|.|....|..|..   |.::::                   |||...|.    |
 Worm   375 DFWMRCFL-LKPVFRTSNRRKYRMNPEEPTQVI-------------------LVSEAKNG----E 415

  Fly   388 DLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKI 452
            .|::.         |.:::|.|                       :|..:|::...:..:.:.|:
 Worm   416 VLTKK---------STELNGTV-----------------------VKEIMLSSRLEALEEYIRKM 448

  Fly   453 HKSCFCVRFIAEHTKMQEDSTKVK----EDWKYVAMVLDRLFLWIFTLAVVVGTA 503
            ...|..:::..:.....|:...|:    ..:..::..||.||:::|...|.:..|
 Worm   449 VNRCETIKWELDEIDAAENIELVRRRSTNGYVRISERLDILFMFLFLSTVTIPVA 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	123/510 (24%)
		Neur_chan_LBD	12..227	CDD:280998	64/221 (29%)
		Neur_chan_memb	234..505	CDD:280999	55/281 (20%)
pbo-5	NP_001024240.1	Neur_chan_LBD	68..272	CDD:280998	64/220 (29%)
		Neur_chan_memb	306..>364	CDD:280999	21/57 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910