Protein Alignment nAChRalpha4 and lgc-1

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_504154.5
• Gene: lgc-1 / 188099
• WormBaseID: WBGene00020236
• Length: 371
• Species: Caenorhabditis elegans
• Alignment Length: 378
• Identity: 89/378 - (23%)
• Similarity: 168/378 - (44%)
• Gaps: 65/378 - (17%)

  Fly    11 DAKRLYDDLLSNYNKLVRPV--------VNTTDVLKVCI-KLKLS----QLIDVNLKNQIMTTNL 62
            |.|||:|||..:|:..:..:        :|.|..:...| :|||:    :|:||....:.:|...
 Worm    15 DQKRLWDDLFKDYDPTLSAIYTLHKSQWINQTATIHPPITELKLTMAMLKLVDVVEVEEKVTFLF 79

  Fly    63 WVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGN----FEVTLATK-ATIYSEG 122
            .....|.|.:|:|.|.||||:..::||...||.|::.:   ||.:    ||...|.: |.|...|
 Worm    80 DYLAEWTDQRLKWNPLEYGGISHIYVPQRMIWLPEVTI---ADAHEVKFFESDDAPRTAWINYNG 141

  Fly   123 LVEWKPPAIYKSSCEIDVEYFPFDEQTCVLK--FGSWTYDGF--KVDLRHMDE---QQGSNVVAV 180
            ...:....:....|::||..||.|...|.:.  |.::..|.:  |.|:..:.:   |.|:.
 Worm   142 TTGFYTSTVSSVICQLDVYKFPLDRHECGVSVLFHTYFADEYVIKSDMEPLPKPLSQLGNG---- 202

  Fly   181 GVDLSEFYMSVEWDILEV---PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGIS 242
                       ||.:..:   ..:.|..|...       ..|...:.|...||...:::|...|:
 Worm   203 -----------EWKVTYIGVAEEIGNGNFSAV-------QRFVARIERNPGFYVTLVMVPAFFIN 249

  Fly   243 FLTVLTFYLPSDS-GEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILV--SIS 304
            ||:::...|..:: |||:|:.::.::::....:::.:.:|.|.. :|||..|:|..:::|  ||.
 Worm   250 FLSIIALCLNIENVGEKITVGLTNIMAMTFILVILAQDLPKTKR-IPLLAIYVIVGLVIVMASIG 313

  Fly   305 ICVTVVVLNVHFRSPQTHK--------MAPWVKRVFIDFLPAFLFIKRPTYNF 349
            :.:|:.::..|.:..|..|        .:.|...:.::::..|:|......||
 Worm   314 VVLTLPLIRNHLKKRQKGKEEKPVETRFSKWFGWLTVEYVVMFVFQLANLINF 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	89/378 (24%)
		Neur_chan_LBD	12..227	CDD:280998	58/242 (24%)
		Neur_chan_memb	234..505	CDD:280999	28/127 (22%)
lgc-1	NP_504154.5	Neur_chan_LBD	84..>335	CDD:332142	66/276 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810