Protein Alignment nAChRalpha4 and lgc-18

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_510029.3
• Gene: lgc-18 / 187977
• WormBaseID: WBGene00011360
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 336
• Identity: 72/336 - (21%)
• Similarity: 149/336 - (44%)
• Gaps: 61/336 - (18%)

  Fly    14 RLYDDLLSNYNKLVRPVVNTTDV-------------LKVCIKLKLSQLIDVNLKNQIMTTNLWVE 65
            :|..|:.:||:..:.||....|.             ....:.|...:|::|....:.::..|.:.
 Worm    36 KLIKDVFTNYDNTLSPVYTKIDPTQPIGYNPLAPKRFNYTVSLYYLKLVEVIEPEEKVSVVLEMA 100

  Fly    66 QSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNAD-----------------GNFEVTLA 113
            :.|||.::.|:...||.:.|||:..|.:|.|.:.|:...|                 |:...||:
 Worm   101 EYWYDPRIAWDSSLYGDIKMLHMRQDKVWSPTLSLFRINDIADFRDPDFRMVCVENTGHTYTTLS 165

  Fly   114 TKATIYSEGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVV 178
            .|.::                :|.:||..||:|.|||.::        |.:.|..|.:.:..:.:
 Worm   166 VKISL----------------NCPLDVSMFPYDSQTCRIQ--------FNMPLFFMQQVEMFSQI 206

  Fly   179 AVGVDLSEFYMSV---EWDILEVP-AVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCM 239
            ..|:..|..:..:   ||::..:. :|....:.....:..| .||.|.:||..::|...||.|..
 Worm   207 YEGILNSTVWEKMGNSEWELANLTHSVELLSYGDGLGDMQL-ATFEIRIRRNPMYYIYMIIFPSF 270

  Fly   240 GISFLTVLTFYL-PSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSI 303
            .|:.|:::..:| .:|...|:.:.::.::::.....::.:.||.|. .:||||.|:|..:.::.:
 Worm   271 IINALSIIGVFLKKTDKMSKLNVGLTNIMTMTFILGVMADKIPKTG-SIPLLGIYIIVNLFIMIV 334

  Fly   304 SICVTVVVLNV 314
            ::.:|:|:..:
 Worm   335 AVGLTIVLAEI 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	72/336 (21%)
		Neur_chan_LBD	12..227	CDD:280998	52/246 (21%)
		Neur_chan_memb	234..505	CDD:280999	19/82 (23%)
lgc-18	NP_510029.3	LGIC_ECD_cation	75..257	CDD:349790	44/206 (21%)
		LGIC_TM_cation	259..>341	CDD:349853	19/82 (23%)
		TM1 helix	263..284	CDD:349853	6/20 (30%)
		TM2 helix	292..313	CDD:349853	0/20 (0%)
		TM3 helix	323..341	CDD:349853	3/17 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810