Protein Alignment nAChRalpha4 and lgc-16

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_510027.2
• Gene: lgc-16 / 187975
• WormBaseID: WBGene00011358
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 365
• Identity: 86/365 - (23%)
• Similarity: 158/365 - (43%)
• Gaps: 72/365 - (19%)

  Fly    13 KRLYDDLLSNYNKLVRPVV-------------NTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWV 64
            :.|.:||.:||:..:..|.             .|.|.....|.|...:|::|....:.::..|.:
 Worm    37 ENLTNDLFANYDPTISTVYADIADWEPLGDNPRTIDRWNYTILLYYLKLVEVQEPAEKVSVVLEL 101

  Fly    65 EQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRP--------DIVLYNNADGNFEVTLATKATIYSE 121
            .:.|||.:|.|....|..|..:....:.:|.|        :|:.:.:.|  |.: ::...|.|..
 Worm   102 VERWYDPRLSWNISLYSNVSTIFARQEKVWSPTLSPFGVNEIIDFRDQD--FRL-ISIDFTGYLN 163

  Fly   122 GLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSE 186
            ..:..:..|    :|.:||..||||.|||.::|....:                |:..|.: |:|
 Worm   164 DYLSVRVSA----NCPMDVSRFPFDSQTCQIRFCLPIF----------------NIRQVKI-LNE 207

  Fly   187 FYMSV------------EWDILEVP-AVRNEKFYTCCDEPY--LDI-TFNITMRRKTLFYTVNII 235
            .|..:            ||.::.:. .|...|:    |:.|  :|: .|.||:||..|:|...|:
 Worm   208 IYEGILQEKIIKTMGNSEWKVVSLTNRVEQLKY----DDDYGNMDLAVFEITIRRNPLYYIYMIV 268

  Fly   236 IPCMGISFLTVLTFYLPS-DSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMI 299
            .|...|:.::::..:|.| |...|:.:.::.::::.....::.:.||.|. .:||||.|:|..::
 Worm   269 FPSFVINGISIVGIFLKSADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-SIPLLGIYIIINLL 332

  Fly   300 LVSISICVTVVVLNVHFRS---PQTHKMAPWVKRVFIDFL 336
            ::.|:|  |||||....|.   |:......::.|....||
 Worm   333 IMIIAI--TVVVLITELRQWAVPRLKLKKSYMSRKLETFL 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	86/365 (24%)
		Neur_chan_LBD	12..227	CDD:280998	56/250 (22%)
		Neur_chan_memb	234..505	CDD:280999	28/107 (26%)
lgc-16	NP_510027.2	LGIC_ECD_cation	77..259	CDD:349790	47/209 (22%)
		LGIC_TM	261..>317	CDD:365787	11/55 (20%)
		TM1 helix	261..284	CDD:349850	5/22 (23%)
		TM2 helix	291..315	CDD:349850	1/23 (4%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810