Protein Alignment nAChRalpha4 and lgc-15

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_510025.2
• Gene: lgc-15 / 187973
• WormBaseID: WBGene00011356
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 327
• Identity: 75/327 - (22%)
• Similarity: 153/327 - (46%)
• Gaps: 51/327 - (15%)

  Fly    15 LYDDLLSNYNKLVRPVVNTTDVLK----------------VCIKLKLSQLIDVNLKNQIMTTNLW 63
            |..:|.|.|:..:.||....|..:                :...||   |::|....:.::..:.
 Worm    38 LTKNLFSGYDATISPVYTKVDPTQPLGHDPDAPGRWNYTLLLFSLK---LVEVTEPQEKVSVVME 99

  Fly    64 VEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDI------VLYNNADGNFEVTLATKATIYSEG 122
            |.:.|:|.:|.|..::|..:..::....::|.|.:      .|.:..|.:|.:     ..|.|.|
 Worm   100 VMEYWFDARLTWNKEDYDDIASIYTRQANVWSPTLSAFGVSELVDLRDTDFRL-----VGITSYG 159

  Fly   123 LVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEF 187
            :|......:..::|.:||..||||.|||.::|....:..::|::        .|.:..||..|..
 Worm   160 MVNTYVSVLVSANCPMDVYKFPFDYQTCQIRFCIPVFTSYEVEI--------FNEIYAGVLTSNA 216

  Fly   188 YMSV---EWDILEVP-AVRNEKFYTCCDEPY--LDI-TFNITMRRKTLFYTVNIIIPCMGISFLT 245
            :.::   ||:::.:. .|...|:    |:.:  ||: ||.|.:||..|:|...||.|...|:.::
 Worm   217 WKTMGNSEWNLVNLTHRVETLKY----DDGFANLDLGTFEIKIRRNPLYYIYMIIFPSFIINVVS 277

  Fly   246 VLTFYLP-SDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTV 309
            ::..:|. :|...|:.:.::.::::.....::.:.||.|. .:||||.|:|..::::.|:|.:..
 Worm   278 IIGVFLKGADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-TIPLLGVYIITNLVIMLIAIGIVT 341

  Fly   310 VV 311
            |:
 Worm   342 VI 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	75/327 (23%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	54/242 (22%)
		Cys-loop	136..150	CDD:349832	8/13 (62%)
lgc-15	NP_510025.2	LGIC_ECD_cation	74..258	CDD:349790	46/203 (23%)
		Cys-loop	173..187	CDD:349790	8/13 (62%)
		LGIC_TM_cation	260..>343	CDD:349853	20/83 (24%)
		TM1 helix	260..285	CDD:349853	7/24 (29%)
		TM2 helix	293..314	CDD:349853	0/20 (0%)
		TM3 helix	324..343	CDD:349853	4/18 (22%)