DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha4 and lgc-14

DIOPT Version :10

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_510024.2 Gene:lgc-14 / 187972 WormBaseID:WBGene00011355 Length:400 Species:Caenorhabditis elegans


Alignment Length:378 Identity:87/378 - (23%)
Similarity:168/378 - (44%) Gaps:61/378 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 DLLSNYNKLVRPVVNTTDVLK-------------VCIKLKLSQLIDVNLKNQIMTTNLWVEQSWY 69
            ||.:.|:..|.||.:..|.|:             ..|.|...:|::||...:.:...:.:.:.||
 Worm    40 DLFNGYDPTVSPVYSKIDPLQPLGYDPDAPKRYNYSIMLYSLKLVEVNEPAEKVAVVMEIMEYWY 104

  Fly    70 DYKLRWEPKEYGGVHMLHVPSDHIWRPDI------VLYNNADGNFEVTLATKATIYSEGLVEWKP 128
            |.:|.|....|..:...:....::|.|.:      .|.:..|.:|.:     ..:.|.|.:....
 Worm   105 DIRLSWNASLYDDIDTFYTRQSNVWSPTLSAFGADELVDLRDPDFRM-----VCVNSNGYIYDYI 164

  Fly   129 PAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSV-- 191
            .....|||.::|..||||.|||.:||....::..::.:        .|.:.|||.:|:.:.::  
 Worm   165 SVRVSSSCPMNVYKFPFDYQTCQIKFCLPIFNSVEIQI--------FNEIYVGVLMSDLWETMGN 221

  Fly   192 -EWDIL----EVPAVR-NEKFYTCCDEPYLDI-TFNITMRRKTLFYTVNIIIPCMGISFLTVLTF 249
             ||.:.    .|..:: |:.|..      ||: .|.||::|..|:|...||.|...|:.::::..
 Worm   222 SEWKLTNLSNRVETLQYNDGFGN------LDLGIFEITIKRNPLYYIYMIIFPSFIINVVSIIGV 280

  Fly   250 YLP-SDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLN 313
            :|. :|...::.:.::.::::.....::.:.||.|. .:|:||.|:|..:.::.|:|.:..::..
 Worm   281 FLKGADKMSRLNVGLTNIMTMTFILGVMADKIPRTG-TIPMLGVYIIVNLAIMIIAIGIVTMITE 344

  Fly   314 VHFRSPQTHKMAPWVKRVFIDF---LPAFLFIKRPTYNFETSKLLLKDTHACF 363
            :.      |.:||::||....|   |..|:   .|...|..:.:|...|.|.|
 Worm   345 LR------HWLAPFLKRNETKFSRKLETFI---GPPLEFTCAIILEVFTCAIF 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:455710 87/378 (23%)
LGIC_ECD_nAChR_proto_alpha-like 11..229 CDD:349832 55/238 (23%)
Cys-loop 136..150 CDD:349832 7/13 (54%)
lgc-14NP_510024.2 LGIC_ECD_cation 75..257 CDD:349790 46/200 (23%)
Cys-loop 172..186 CDD:349790 7/13 (54%)
LGIC_TM 259..349 CDD:476813 19/96 (20%)
TM1 helix 263..284 CDD:349850 5/20 (25%)
TM2 helix 292..313 CDD:349850 0/20 (0%)
TM3 helix 323..345 CDD:349850 4/21 (19%)

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