Protein Alignment nAChRalpha4 and lgc-14

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_510024.2
• Gene: lgc-14 / 187972
• WormBaseID: WBGene00011355
• Length: 400
• Species: Caenorhabditis elegans
• Alignment Length: 378
• Identity: 87/378 - (23%)
• Similarity: 168/378 - (44%)
• Gaps: 61/378 - (16%)

  Fly    18 DLLSNYNKLVRPVVNTTDVLK-------------VCIKLKLSQLIDVNLKNQIMTTNLWVEQSWY 69
            ||.:.|:..|.||.:..|.|:             ..|.|...:|::||...:.:...:.:.:.||
 Worm    40 DLFNGYDPTVSPVYSKIDPLQPLGYDPDAPKRYNYSIMLYSLKLVEVNEPAEKVAVVMEIMEYWY 104

  Fly    70 DYKLRWEPKEYGGVHMLHVPSDHIWRPDI------VLYNNADGNFEVTLATKATIYSEGLVEWKP 128
            |.:|.|....|..:...:....::|.|.:      .|.:..|.:|.:     ..:.|.|.:....
 Worm   105 DIRLSWNASLYDDIDTFYTRQSNVWSPTLSAFGADELVDLRDPDFRM-----VCVNSNGYIYDYI 164

  Fly   129 PAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSV-- 191
            .....|||.::|..||||.|||.:||....::..::.:        .|.:.|||.:|:.:.::
 Worm   165 SVRVSSSCPMNVYKFPFDYQTCQIKFCLPIFNSVEIQI--------FNEIYVGVLMSDLWETMGN 221

  Fly   192 -EWDIL----EVPAVR-NEKFYTCCDEPYLDI-TFNITMRRKTLFYTVNIIIPCMGISFLTVLTF 249
             ||.:.    .|..:: |:.|..      ||: .|.||::|..|:|...||.|...|:.::::..
 Worm   222 SEWKLTNLSNRVETLQYNDGFGN------LDLGIFEITIKRNPLYYIYMIIFPSFIINVVSIIGV 280

  Fly   250 YLP-SDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLN 313
            :|. :|...::.:.::.::::.....::.:.||.|. .:|:||.|:|..:.::.|:|.:..::..
 Worm   281 FLKGADKMSRLNVGLTNIMTMTFILGVMADKIPRTG-TIPMLGVYIIVNLAIMIIAIGIVTMITE 344

  Fly   314 VHFRSPQTHKMAPWVKRVFIDF---LPAFLFIKRPTYNFETSKLLLKDTHACF 363
            :.      |.:||::||....|   |..|:   .|...|..:.:|...|.|.|
 Worm   345 LR------HWLAPFLKRNETKFSRKLETFI---GPPLEFTCAIILEVFTCAIF 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	87/378 (23%)
		Neur_chan_LBD	12..227	CDD:280998	55/236 (23%)
		Neur_chan_memb	234..505	CDD:280999	30/134 (22%)
lgc-14	NP_510024.2	LGIC_ECD_cation	75..257	CDD:349790	46/200 (23%)
		LGIC_TM	259..349	CDD:365787	19/96 (20%)
		TM1 helix	259..284	CDD:349850	7/24 (29%)
		TM2 helix	292..313	CDD:349850	0/20 (0%)
		TM3 helix	323..345	CDD:349850	4/21 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810