Protein Alignment nAChRalpha4 and lgc-13

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_510023.2
• Gene: lgc-13 / 187971
• WormBaseID: WBGene00011354
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 319
• Identity: 72/319 - (22%)
• Similarity: 141/319 - (44%)
• Gaps: 36/319 - (11%)

  Fly    18 DLLSNYNKLVRPVVNTTDVLK-------------VCIKLKLSQLIDVNLKNQIMTTNLWVEQSWY 69
            ||..||.|.|.||....|..|             ..:.|...:||.||...:.::..|.:.:.||
 Worm    41 DLFKNYEKDVSPVYAWFDTSKPLGYDPDAPQRYNYTLFLYNLKLIQVNEPEEQVSVVLELMEYWY 105

  Fly    70 DYKLRWEPKEYGGVHMLHVPSDHIWRPDIV------LYNNADGNFE-VTLATKATIYSEGLVEWK 127
            |.:|.|...:|..|..:....:.||.|.:.      :.:..|.:|. |.:.....||....|.
 Worm   106 DPRLSWNASDYKNVTAIFTRQEKIWSPTLTPFGVNEIIDFRDQDFRLVCIDNLGMIYDYLSVR-- 168

  Fly   128 PPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVE 192
                ..::|.:||..||||.|||.::|....:...:|.: :.:..:|.|    ...:.|...:.|
 Worm   169 ----VSANCRMDVTKFPFDSQTCQIRFSLPIFSYLEVKI-YTELYEGIN----NYSMFEVMGNSE 224

  Fly   193 WDILEVPAVRNEKFYTCCDEPYLDI-TFNITMRRKTLFYTVNIIIPCMGISFLTVL-TFYLPSDS 255
            |:::.:  .....|.|..|...::: .:.|.:.|..|:|...|:.|...|:.:::: .|...:|.
 Worm   225 WELINL--TNRVDFLTYNDRFDVELAVYEIKIARNPLYYFYMIVFPSFVINSVSIVGVFIKGADK 287

  Fly   256 GEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNV 314
            ..::.:.::.::::.....::.:.||.|. .|||||.|:|..::::.::|.:..::..:
 Worm   288 MSRLNVGLTNIMTMTFILGVMSDKIPRTG-NVPLLGIYIIVNLLIMLVAIIIVTIITEI 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	72/319 (23%)
		Neur_chan_LBD	12..227	CDD:280998	54/229 (24%)
		Neur_chan_memb	234..505	CDD:280999	16/82 (20%)
lgc-13	NP_510023.2	LGIC_ECD_cation	74..257	CDD:349790	43/195 (22%)
		LGIC_TM	259..>335	CDD:365787	17/76 (22%)
		TM1 helix	259..284	CDD:349850	6/24 (25%)
		TM2 helix	292..313	CDD:349850	0/20 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810