Protein Alignment nAChRalpha4 and lgc-9

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_500341.1
• Gene: lgc-9 / 182195
• WormBaseID: WBGene00015412
• Length: 464
• Species: Caenorhabditis elegans
• Alignment Length: 514
• Identity: 116/514 - (22%)
• Similarity: 208/514 - (40%)
• Gaps: 115/514 - (22%)

  Fly    15 LYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPKE 79
            |.:.:...|:|.|||...:...:.|.:.:.|..|.:|....|:.:..:...|.|.|.||.|.|.:
 Worm    44 LIETIQRRYDKRVRPFAESNRPVIVHMTIVLGILTEVRENQQVASFVISHVQKWRDPKLAWNPAD 108

  Fly    80 YGGVHMLHVPSDHIWRPDIVLYNN-------ADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCE 137
            :.|:..:.:|...:|.|.:.:||:       .|..::|      .|...|.|:...|....:.|.
 Worm   109 HSGLTQVVMPRSLVWVPKLFIYNSMDTKDMLTDDRYDV------RIQHTGHVKVNSPQFVSTLCR 167

  Fly   138 IDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVR 202
            |:::.||||.|.|.:...|......::|:         |.....|| |.|..:.||.::.| .|:
 Worm   168 INIDLFPFDTQFCAIALASPLLSVEEMDV---------NATQPPVD-SYFSGNAEWQVMNV-TVK 221

  Fly   203 NEKFYTCCDEPY-LDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLP-SDSG---EKVTLS 262
            ..||..  :..| .::.:.:.:.|:..:|...|::|...||.|::|..:.| |:.|   |||:|.
 Worm   222 QMKFME--EGEYRAEVHYILHLNRRPTYYITVIVVPTFLISALSILGIFSPGSNDGPRNEKVSLG 284

  Fly   263 ISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPW 327
            :..|:::.|...:|...:|.:. .:||||.|::..::|.:|.:.|::.:|::.....||.||.|
 Worm   285 LGSLLAMTVLLDIVAGAMPKSD-AIPLLGYYIMLVILLCAIGVAVSMAMLSMSRSCIQTSKMPP- 347

  Fly   328 VKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQS 392
                             |.|    .:||.             .|:.|:|..  |:.|....:::.
 Worm   348 -----------------PHY----YRLLF-------------LNVCRVVKQ--NSGLNGVAMNEK 376

  Fly   393 ITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCF 457
            .||..|                       ..||:        ..|.|.        |.::.::
 Worm   377 PTAITP-----------------------RFPDL--------IAIYNQ--------LIEVARA-- 400

  Fly   458 CVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIF----TLAVVVGTAGIILQAPTL 512
             .|...|..:.|:...:|:.:|..:...:|..||::|    .|.:|:......|..|.|
 Worm   401 -QRTYRERIEKQKWQHRVEIEWNKIFARIDFFFLFLFEMFNVLILVLFLRCAFLPVPPL 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	113/505 (22%)
		Neur_chan_LBD	12..227	CDD:280998	53/219 (24%)
		Neur_chan_memb	234..505	CDD:280999	59/278 (21%)
lgc-9	NP_500341.1	Neur_chan_LBD	42..245	CDD:280998	53/219 (24%)
		Neur_chan_memb	252..>347	CDD:280999	30/95 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810