Protein Alignment nAChRalpha4 and acr-8

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001361818.1
• Gene: acr-8 / 181246
• WormBaseID: WBGene00000047
• Length: 540
• Species: Caenorhabditis elegans
• Alignment Length: 526
• Identity: 217/526 - (41%)
• Similarity: 311/526 - (59%)
• Gaps: 70/526 - (13%)

  Fly     9 NPD--AKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDY 71
            ||:  |.::|:|||..|||.|||:.|.::.:||.....|.::|||:..||::|||||:|..|:||
 Worm    20 NPNRYADQMYEDLLYYYNKNVRPIKNASESVKVKFGSSLIRIIDVDEVNQVLTTNLWLEMQWFDY 84

  Fly    72 KLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSC 136
            :|.|:|..:|.:..||||.|.||.|||:|||||||...:|:.:.|.:|..|||.||||:||||.|
 Worm    85 RLMWDPGRWGKIRKLHVPVDQIWIPDILLYNNADGEPHITIMSDAIVYYNGLVVWKPPSIYKSFC 149

  Fly   137 EIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHM-----------DEQQGSNVVAVGVDLSEFYMS 190
            .||:||||:|.|||.:|||.|||:||.:|:|.:           |::.....:..|:|||.:|.|
 Worm   150 SIDIEYFPYDTQTCWMKFGGWTYNGFLLDVRQLPTTGCEVVNKADDEGEFQFLGRGMDLSGYYPS 214

  Fly   191 VEWDILEVPAVRNEKFYT-CCDEP-YLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPS 253
            :|||::|:.:.|:||.|. ||.:. |:||||.|.:||||||||:|::|||...:.||.:.||:|.
 Worm   215 LEWDLMELNSARHEKIYAGCCGQDFYIDITFKIEIRRKTLFYTINLMIPCTMFAILTSIVFYVPP 279

  Fly   254 DSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRS 318
            .. .|:|.|||||::|.||:|::::::||||||:||:||||:|.|.||||||.::|:.||.:.|.
 Worm   280 IE-HKMTFSISILVTLTVFYLILIDLVPPTSLVIPLIGKYLLFTMFLVSISIMLSVISLNFYRRD 343

  Fly   319 PQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNS 383
            ..:..|..|:|.|||..||.::.||                        :|...|
 Worm   344 GSSFPMPHWMKVVFIHTLPRYICIK------------------------TAEEDD---------- 374

  Fly   384 LPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKC 448
              ..|...||:..|||..|   ..|.|.....:..::..... ::...||...::.|...:
 Worm   375 --GSDRGSSISDIGPFMDS---RRPSPFFITVNERQLNGRLS-ELKKKGMHPDLIRNMIQN---- 429

  Fly   449 LPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLY 513
                      |.||||:....:...||.|||.|||.|:||:||.||::..||||..|:|.:|.|:
 Worm   430 ----------VEFIAEYFNSLKKEDKVSEDWSYVANVIDRIFLIIFSIMNVVGTWVILLNSPALF 484

  Fly   514 DDRIPI 519
            |:|.|:
 Worm   485 DNRTPL 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	210/510 (41%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	112/232 (48%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
acr-8	NP_001361818.1	LGIC_ECD	24..255	CDD:475126	112/230 (49%)
		Neur_chan_memb	260..476	CDD:460753	91/270 (34%)