Protein Alignment nAChRalpha4 and lgc-11

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_509270.1
• Gene: lgc-11 / 181009
• WormBaseID: WBGene00000061
• Length: 434
• Species: Caenorhabditis elegans
• Alignment Length: 336
• Identity: 99/336 - (29%)
• Similarity: 164/336 - (48%)
• Gaps: 34/336 - (10%)

  Fly    12 AKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWE 76
            ||.|.||    |.:..|||.|.:.||.|.::.::..|::||.:|:.:...||..|||.|..|.|:
 Worm    40 AKHLLDD----YYQYTRPVRNYSSVLNVTVQPQIYNLVEVNEQNEQIKILLWFPQSWKDDYLTWD 100

  Fly    77 PKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVE 141
            |||:.|:..:.:|...||.||..::|..: ..|......|.:..:|.||.....:...:|.:.|.
 Worm   101 PKEWNGIERIIIPKSQIWIPDGYIFNTVE-ETEPLENHNARVRYDGRVEVDFNKLVDLTCPMSVL 164

  Fly   142 YFPFDEQTCVLKFGSWTYDGFKVDLRHMD---EQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRN 203
            .||||.|.|.|:||||:|....:....:|   .::..|              .||||:...|.:.
 Worm   165 SFPFDVQLCALQFGSWSYQAHAISFNVLDTFVPKKSKN--------------SEWDIVSFNATKM 215

  Fly   204 EKFYTCCD-----EPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLP----SDSGEKV 259
            ...|.  |     ..|.:|.:.:.:|||.|:|.|.|::|...|..::.:..:.|    .|..|.|
 Worm   216 TTKYG--DTLGGFNVYEEIFYYLELRRKPLYYIVVILLPSFLIVTVSNIGLFTPHGVHGDREEHV 278

  Fly   260 TLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKM 324
            :|.::.::::.|...:|...:|.:|..:||||.|::...::..|::.|:||::..|.|.......
 Worm   279 SLGLTTMLTMAVILDMVTGQMPRSSEGIPLLGMYVLIEFVISVIAVLVSVVIIFAHERMLYLDAT 343

  Fly   325 AP-WVKRVFID 334
            .| ||.::|.|
 Worm   344 PPYWVCKLFSD 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	99/336 (29%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	68/224 (30%)
		Cys-loop	136..150	CDD:349832	7/13 (54%)
lgc-11	NP_509270.1	LIC	8..>334	CDD:455710	92/314 (29%)