Protein Alignment nAChRalpha4 and acr-3

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_509129.1
• Gene: acr-3 / 180937
• WormBaseID: WBGene00000043
• Length: 487
• Species: Caenorhabditis elegans
• Alignment Length: 517
• Identity: 181/517 - (35%)
• Similarity: 283/517 - (54%)
• Gaps: 67/517 - (12%)

  Fly     9 NPDAKRLYDDLLSNYNKLVRPVVN-TTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYK 72
            |...:||...:...||.|:|||:| ::..::|...|....||:|:.|||||.||:|....|.||:
 Worm    23 NSAEERLLSYIFDGYNSLIRPVLNASSPPIEVFFSLAFVLLINVDEKNQIMQTNVWPTMKWNDYQ 87

  Fly    73 LRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCE 137
            ::|:|:|:.|:..:.||.|.:|.|||||:||||||:.|:..:...:...|.:.|.|||:|||||.
 Worm    88 MQWDPREFDGIKTIRVPPDKVWLPDIVLFNNADGNYLVSFYSNVVVEHTGDMLWVPPAVYKSSCL 152

  Fly   138 IDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVR 202
            ||||:||||||.|.|.|||||:...::.|.::..::       .|:|:::..|..||:::.|.:
 Worm   153 IDVEFFPFDEQVCSLTFGSWTFRKDELQLSYLSGKR-------HVELNDYLPSGVWDLIDAPGL- 209

  Fly   203 NEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILI 267
                  ..|| ...|::.|.:|||.|||||.:|:|.:.::||:::.||||::|.||:||:||||:
 Worm   210 ------LIDE-RSKISYQIKIRRKALFYTVILIMPTVLMAFLSMMVFYLPAESSEKITLAISILL 267

  Fly   268 SLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVF 332
            :|.||.|:|.:|:||||..:||:.|||:...|:..|:|.|:|:::||:||.|.||.|..|||.||
 Worm   268 ALVVFLLVVSKILPPTSSTIPLMAKYLLMTFIMNMITIMVSVIIINVYFRGPATHIMPNWVKTVF 332

  Fly   333 IDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANG 397
            :.|||....::||.   .|.|.|.|        ........|.:.|.......:.|.
 Worm   333 LKFLPVLFVMRRPE---STEKELAK--------MKREKRERRSMKSALKTFFKRNDA-------- 378

  Fly   398 PFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFI 462
                                 :|:..|         |.....:.:.|..|......|:...:.:|
 Worm   379 ---------------------KISEQP---------KQTSRKDGSSSEEKLSSDAKKAIEAIEYI 413

  Fly   463 AEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYD--DRIPIIEQ 522
            ..|........:.:|:||:|::|:|||.|::|......||.||:|.||.:::  ::..:||:
 Worm   414 TTHLTHDNAFKRQREEWKFVSVVIDRLLLYLFFAVTTGGTVGILLSAPNVFEQVNQTSVIER 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	174/496 (35%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	86/218 (39%)
		Cys-loop	136..150	CDD:349832	11/13 (85%)
acr-3	NP_509129.1	LIC	5..460	CDD:455710	177/500 (35%)
		LGIC_ECD_nAChR_proto_beta-like	25..227	CDD:349833	85/216 (39%)
		Cys-loop	151..165	CDD:349833	11/13 (85%)