Protein Alignment nAChRalpha4 and acr-2

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_509128.1
• Gene: acr-2 / 180936
• WormBaseID: WBGene00000042
• Length: 575
• Species: Caenorhabditis elegans
• Alignment Length: 548
• Identity: 221/548 - (40%)
• Similarity: 309/548 - (56%)
• Gaps: 79/548 - (14%)

  Fly    11 DAKRLYDDLLSNYNKLVRPVVN-TTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLR 74
            |..||..||...||.|:|||.| ::..:.|...:.:..||:|:.||||:.||:|:...|.|::|.
 Worm    59 DEDRLVIDLFREYNFLIRPVKNVSSPPVVVDFGVAMILLINVDEKNQILQTNVWLTMKWNDFQLA 123

  Fly    75 WEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEID 139
            |.|.|||.:..||||||.:|.|||||:||||||:||:..:...:...|.|.|.|||::||||.||
 Worm   124 WNPAEYGNISNLHVPSDRVWLPDIVLFNNADGNYEVSFKSNVFVDHHGDVTWVPPAMFKSSCRID 188

  Fly   140 VEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNE 204
            ||:||||||.|.|.||||||:..:|.|...:..|       .|.|.::..|..||:::||.....
 Worm   189 VEWFPFDEQCCTLVFGSWTYNSEEVRLHWYNNIQ-------AVQLHDYSYSGIWDVIDVPGQLVH 246

  Fly   205 KFYTCCDEPYL---DITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISIL 266
            |       |.|   .:.||:.:|||||||||.:|||.:.::||:|:.||||.||||||:|:||:|
 Worm   247 K-------PDLKENKMVFNVVIRRKTLFYTVILIIPTVLMAFLSVMAFYLPVDSGEKVSLTISLL 304

  Fly   267 ISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRV 331
            ::|.||.|||.:|:|||| .:||:||||:.|.:|...::..|||::|::|||..:|||..||::|
 Worm   305 LALVVFLLLVSKILPPTS-NIPLMGKYLLLAFVLNITAVVGTVVIVNIYFRSALSHKMPTWVRKV 368

  Fly   332 FIDFLPAFLFIKR----PTYN------------FETSKLLLKDTHACFYPYYS-ATNIDRL--VS 377
            |::|||..|.:||    |.:|            |:.| |::....|...|:.. .||:...  .|
 Worm   369 FLEFLPHLLVMKRPERIPIFNGYFVEEYCASEIFDAS-LVMPSMTATMLPFLQVTTNLKAASSTS 432

  Fly   378 SGY------NNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSP 436
            ||.      |.|..|:.||..::..         ..|...|...|.|
 Worm   433 SGQSSEHHENCSKWKKRLSIRMSKR---------RAPRARLDDDSED------------------ 470

  Fly   437 ILNNPAFSHSKCL-PKIHK----SCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTL 496
            |:::...:|...| .||.|    :...:.:||||.|.:....|:::||||||||||||.|.||..
 Worm   471 IIDDTNGNHVDSLQEKISKEMKTTVEAIAYIAEHMKREMSLKKMRDDWKYVAMVLDRLILLIFFG 535

  Fly   497 AVVVGTAGIILQAPTLYD--DRIPIIEQ 522
            ..:.||.|||..||.::|  |:..||.:
 Worm   536 VTLGGTLGIICSAPHVFDFVDQEAIISK 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	212/527 (40%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	98/221 (44%)
		Cys-loop	136..150	CDD:349832	11/13 (85%)
acr-2	NP_509128.1	LIC	54..544	CDD:455710	212/527 (40%)
		LGIC_ECD_nAChR_proto_beta-like	59..265	CDD:349833	96/219 (44%)
		Cys-loop	185..199	CDD:349833	11/13 (85%)