Protein Alignment nAChRalpha4 and des-2

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001380111.1
• Gene: des-2 / 179574
• WormBaseID: WBGene00000955
• Length: 559
• Species: Caenorhabditis elegans
• Alignment Length: 560
• Identity: 147/560 - (26%)
• Similarity: 245/560 - (43%)
• Gaps: 105/560 - (18%)

  Fly    10 PDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLR 74
            |...||..|||.||:|..:|:.:.:..:.|...:.|.|::::|...|.:..|.|:.:.|:|..|.
 Worm    24 PTQIRLVHDLLDNYDKKAKPMWDNSKPINVSFSMDLYQILELNEPQQYILLNAWIIERWFDEFLY 88

  Fly    75 WEPKEYGGVHMLHVPSDHIWRPDIVLYNN---ADGNFEVTLATKATIYSE---GLVEWKPPAIYK 133
            |.|.:|..:..|.:|.|.||.||..|||:   .|.:....|.:|.|..:.   .|:|...|.|||
 Worm    89 WNPDDYENITELRLPYDSIWLPDTTLYNSLVMKDDDTRRLLNSKLTTDTHRRAALIELLYPTIYK 153

  Fly   134 SSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEV 198
            .||.:|:.:||||.|.|.:.|.|||||...:|.....::.|:         |.:..:..|.||:.
 Worm   154 FSCLLDLRFFPFDVQVCTMTFSSWTYDQKGIDYFPYSDKIGT---------SNYLENEGWYILQT 209

  Fly   199 PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSG----EKV 259
            ...|.|..|.||...|..:...:.:|||.|||.||:|||...|:.:.::.|:..|.:.    |||
 Worm   210 KIKRQEVKYACCPNNYTLLQLTLYLRRKPLFYLVNLIIPTSIITLIAIVGFFTTSSASGMREEKV 274

  Fly   260 TLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKM 324
            :|.|:.|:|:.:..|:|.:.:|.||..:||:|.:::..:|::|:...|:.|::.:..|.....:|
 Worm   275 SLGITTLLSMSILMLMVSDQMPTTSTFIPLIGWFILAMIIVISLGTVVSSVIIAIQKRGSLGERM 339

  Fly   325 A-------------------PWVKR-----------VFIDFLPAFLF-------------IKRPT 346
            :                   |.|::           ..::..|..|.             .:|.|
 Worm   340 SKRALKFAKVLAWFTCTSLPPHVEKEHMMEAFDAPTPLVEVRPLQLASVKESVRNKWVSGARRAT 404

  Fly   347 YNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQS---ITANGPFGGSCQVHGP 408
            ....:...|:.|           .:.|.|:........|.|.:|.|   :.::.|.
 Worm   405 QRGNSGLALISD-----------KSTDPLIHLSPTAHQPDESISPSAPPVPSSSPL--------- 449

  Fly   409 VPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHK-SCFCV--RFIAEHTKMQE 470
            .||||...:|::.:|    ...|..|        |..|:..||..| :.|..  |.....:.|::
 Worm   450 PPPLTPGPADDVVSV----ASELSSK--------FLTSRMRPKSQKDNTFAAMQRAGLSRSSMRQ 502

  Fly   471 DSTKVKE-----DWKYVAMVLDRLFLWIFTLAVVVGTAGI 505
            .|.|...     ::::.|.|::|....||.:|.::.|.||
 Worm   503 GSIKANRQLAVAEFEWFATVVERTCFVIFVVAFLIITFGI 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	145/558 (26%)
		Neur_chan_LBD	12..227	CDD:280998	71/220 (32%)
		Neur_chan_memb	234..505	CDD:280999	67/328 (20%)
des-2	NP_001380111.1	Neur_chan_LBD	28..222	CDD:397192	67/202 (33%)
		LGIC_TM_cation	239..>332	CDD:349853	30/92 (33%)
		TM1 helix	243..263	CDD:349853	7/19 (37%)
		TM2 helix	275..296	CDD:349853	6/20 (30%)
		TM3 helix	307..329	CDD:349853	4/21 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010