DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha4 and lgc-26

DIOPT Version :9

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_503167.1 Gene:lgc-26 / 178554 WormBaseID:WBGene00021981 Length:486 Species:Caenorhabditis elegans


Alignment Length:540 Identity:114/540 - (21%)
Similarity:215/540 - (39%) Gaps:115/540 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 AVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWY 69
            |.:.:.|.::|...||..||..||||...:.|.:|.:.|.::.:..|:...|....:..:..||.
 Worm    20 AASQSTDERKLEAQLLKGYNSKVRPVKVESTVTQVAVYLNIAHVEKVDEHEQTALVHGHLMASWT 84

  Fly    70 DYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLAT--KATIYSEGLVEWKPPAIY 132
            |..|:||.|. ..:..|.:.|..:|:|.:.|||:|.||......|  .|.:|:.|.|..:....:
 Worm    85 DEYLKWERKA-TNISTLSIASSKLWQPALQLYNSARGNSWSLYLTGLPAIVYNTGKVWSRGTFSF 148

  Fly   133 KSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVE----- 192
            ..:|:.|...:|:|:|:|.:....|.|...:|:|       .....|.|.......:|.:     
 Worm   149 FVTCQFDFTNWPYDQQSCPIVITDWVYGLGQVNL-------SDPATAAGYGKPTIRLSYDPIDET 206

  Fly   193 -------WDILEVPAVRNEKFY---TCCD-EP-------YLDITFNITMRRKTLFYTVNIIIPCM 239
                   |::::  :.:...::   .|.| ||       :..:.|.||::|...::::.|::|.:
 Worm   207 NKRHVGGWEVID--SWKKHCYWGPKGCLDAEPDGNPDWYWSLLEFGITLKRHLPYFSLTIVMPMV 269

  Fly   240 GISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSIS 304
            ..|.:.:|.|::.:.......::::|.:.. .:...::..:||.|...|.: .:|....:|:|..
 Worm   270 STSLMILLGFWIENFDFNVFLITLNIALQA-TYGSNILSRMPPGSGRTPKI-VHLYSIGLLISAF 332

  Fly   305 ICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPAFLFIKRPT-YNFETSKLLLKDTHACFYPYYS 368
            ..|.:|:.|                         ||.::.|: |.|:..              |.
 Worm   333 QVVLIVMSN-------------------------FLRVRLPSHYEFDFG--------------YD 358

  Fly   369 ATNIDRLVSSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIG---P 430
            .|.|.:           |..|::..|..|......::..|. .||  |..||.......||   |
 Worm   359 ITEIPK-----------KFGLTRFFTTKGLSFDPQELLNPA-QLT--SEAEIQKEASTSIGISNP 409

  Fly   431 L---GMKSPILNNPAFSHSKCLPKIHKSCFCVRF----IAEHTKMQEDSTKVKEDWKYVAMVLDR 488
            |   |..:.:|.|        |||..::....|.    :.:..|.|::|.|.....:...:.:.|
 Worm   410 LAESGSDTDLLIN--------LPKNSEADLSERSETLGMPDSEKTQKESQKKMRKLEIQLLHIKR 466

  Fly   489 ------LFLWIFTLAVVVGT 502
                  :|:::|.:.:|:.|
 Worm   467 FAFFFVIFVYLFAILLVLAT 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:273305 114/540 (21%)
Neur_chan_LBD 12..227 CDD:280998 58/239 (24%)
Neur_chan_memb 234..505 CDD:280999 54/286 (19%)
lgc-26NP_503167.1 LGIC_ECD_cation 52..256 CDD:349790 47/213 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.910

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