Protein Alignment nAChRalpha4 and lev-1

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001255705.1
• Gene: lev-1 / 178269
• WormBaseID: WBGene00002974
• Length: 507
• Species: Caenorhabditis elegans
• Alignment Length: 535
• Identity: 200/535 - (37%)
• Similarity: 300/535 - (56%)
• Gaps: 97/535 - (18%)

  Fly    11 DAK-RLYDDLLSNYNKLVRPVVNTTDV-LKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKL 73
            ||: ||..||...||.||:||.|.::: :.|.|.::|..||:|:.|.|:|.||:|:...|.|::|
 Worm    36 DAEDRLMVDLFRGYNSLVQPVRNRSELPMIVKIGMQLVLLINVDEKEQVMHTNVWLTMKWDDFQL 100

  Fly    74 RWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEI 138
            :|:|::|..:..:.|..:.:|.|||||:||||||:||:......|.|.|.|.|.|||||||||.|
 Worm   101 KWDPRDYANITQIRVAPEKVWLPDIVLFNNADGNYEVSFMCNVLILSTGTVLWVPPAIYKSSCII 165

  Fly   139 DVEYFPFDEQTCVLKFGSWTY--DGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAV 201
            |||:||||:|.|.|.||||||  |..|:|....|.          ||.||:..|..||:::.|||
 Worm   166 DVEFFPFDDQLCSLTFGSWTYNRDEIKLDFLTSDR----------VDFSEYSTSSIWDMMDGPAV 220

  Fly   202 ----RNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLS 262
                |:.            |.|.|.:|||||||||.:|:|.:.::||.|..||||:.||||:.|:
 Worm   221 LTSDRSR------------IEFQIRIRRKTLFYTVVLILPTVLMAFLNVTVFYLPTASGEKMGLT 273

  Fly   263 ISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPW 327
            :::|:|:.||.|||.:|:||||..:||:.|||:...:|..|:|.||.::.|::||||.||::.||
 Worm   274 MNVLLSIVVFLLLVSKILPPTSSSIPLVAKYLLLTFVLNIITIMVTTIICNIYFRSPITHRLPPW 338

  Fly   328 VKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQS 392
            |::||:|.||..:.::||     ..|.:::.:|.            ||:.:|           .|
 Worm   339 VRKVFLDILPLLMCMQRP-----HRKNVIQRSHR------------RLLETG-----------PS 375

  Fly   393 ITANGPFGGSCQVHGPVPPLTH----C-----SSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKC 448
            :..|....|.   |.|:...||    |     .|||:    |.::.
 Worm   376 VEENPMRSGE---HHPLCRHTHNQDSCRRVRIQSDEL----DDELS------------------- 414

  Fly   449 LPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTL- 512
             |:..::...:.||.|:.:.:|.:.:.::|||::|.|:||..|:.|..|.|.||.|||..||::
 Worm   415 -PEAQRAIDAIEFITENRRDEEITKQFRDDWKFIASVVDRFLLYGFFGATVGGTIGIIFTAPSVF 478

  Fly   513 --YDDRIPIIEQKDL 525
              :|:...:::.|.|
 Worm   479 ETFDENATLVKLKQL 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	192/510 (38%)
		Neur_chan_LBD	12..227	CDD:280998	96/222 (43%)
		Neur_chan_memb	234..505	CDD:280999	88/279 (32%)
lev-1	NP_001255705.1	LIC	15..474	CDD:273305	195/514 (38%)
		Neur_chan_LBD	38..238	CDD:280998	95/221 (43%)
		Neur_chan_memb	245..470	CDD:280999	88/279 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920