Protein Alignment nAChRalpha4 and cup-4

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_498710.2
• Gene: cup-4 / 176104
• WormBaseID: WBGene00000845
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 376
• Identity: 71/376 - (18%)
• Similarity: 142/376 - (37%)
• Gaps: 93/376 - (24%)

  Fly    15 LYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPKE 79
            |...:...||...||:.|.:....|.:...:.. :.:|.:.|.||.:..:...|:|..|.|:||:
 Worm    51 LEQKIFRGYNPKNRPMKNASFPTIVDVHWHIIH-VSINQREQTMTVHGHIYMRWFDEFLVWDPKD 114

  Fly    80 YGGVHMLHVPSDHIWRPDIVLYNNADG---NFEVTLATKATIYSEG----LVEWKPPAIYKSSCE 137
            :..:....|....:|:|.|.:.|:|.|   .|:.:.:....|...|    .||..|....|..|.
 Worm   115 FNNIQYARVKKWQVWQPKIKVSNSASGLGSAFDFSTSAHVIIQMMGKDRAKVEMYPTFSIKVGCA 179

  Fly   138 IDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHM-----------DEQQGSNVVA------------ 179
            .|...:|:|...|.:...| |.....|.|:::           :||:...:::
 Worm   180 FDFTDYPYDLNKCAINLFS-TSTMADVQLQNLYAIPPTLSFGWEEQKMKRIISDFKIQNVSSSAL 243

  Fly   180 --------VGVDLSEFYMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIII 236
                    ....::.|.:...|.:|.|                     .::..|.:..:...::.
 Worm   244 YYTNGNITSSAPITGFDLGSTWSMLAV---------------------TVSFVRHSPLFEAAVVT 287

  Fly   237 PCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLV-----VEIIPPTSLVVPLLGKYLIF 296
            ||:.::.|..:||::.|.|      |..:|:.||.:..|:     ||.:|.:...:|       |
 Worm   288 PCIVVASLISMTFFIDSLS------STFLLMMLHFYVQLIFLHDLVEKLPLSVSEIP-------F 339

  Fly   297 AMILVSISICVTVVVLNVH--------FRSPQTHKMAPWVKRVFI--DFLP 337
            .:.|:.|.:....:.|.:|        ::.|...::    .::|:  :::|
 Worm   340 CIKLIGILMYTNGLTLVLHSSLLCGSYYKCPVPQQL----NKIFVIEEYIP 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	71/376 (19%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	47/251 (19%)
		Cys-loop	136..150	CDD:349832	4/13 (31%)
cup-4	NP_498710.2	LGIC_ECD_cation	73..246	CDD:349790	36/174 (21%)
		Cys-loop	178..192	CDD:349790	4/13 (31%)