Protein Alignment nAChRalpha4 and acr-7

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_495647.1
• Gene: acr-7 / 174262
• WormBaseID: WBGene00000046
• Length: 538
• Species: Caenorhabditis elegans
• Alignment Length: 528
• Identity: 174/528 - (32%)
• Similarity: 272/528 - (51%)
• Gaps: 62/528 - (11%)

  Fly     6 VAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYD 70
            |.|:....:||.|||:||:.|||||.|....|.|.:|:.:.|::.|:.|:|::..|.|::..|.|
 Worm    25 VEGSKKEAQLYRDLLTNYSYLVRPVRNPKKALTVTMKVFIQQVLLVDAKHQMIEVNAWLKYIWTD 89

  Fly    71 YKLRWEPKEYGGVHMLHVP-SDHIWRPDIVLYN----NADGNFEVTLATKATIYSEGLVEWKPPA 130
            ::|||.|.:|..:..:... .|.||:|||:|||    :...:|::|..|.|..||:|::.|.||.
 Worm    90 FRLRWNPLDYENITSVRFQGEDQIWQPDILLYNRYIEDEQESFDITYKTNAVAYSDGVINWIPPG 154

  Fly   131 IYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDI 195
            |:|.||::|:..||||||.|.:|||||||.||.:||| :|..:|....|   |||.:..:.||.:
 Worm   155 IFKLSCKMDITLFPFDEQICFMKFGSWTYHGFALDLR-LDVVKGQEPSA---DLSTYITNGEWHL 215

  Fly   196 LEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLP-SDSGEKV 259
            |..||.|.||||.||.|||..:.|.:.:||:|.:|..|:::|.:.:||:::|.|.|| :|..||:
 Worm   216 LSAPARREEKFYKCCKEPYPTVKFYLHLRRRTFYYVFNVVLPTLLVSFMSLLAFCLPATDLSEKI 280

  Fly   260 TLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKM 324
            .|..:||:|:..|..::.|:.|.||..|||||.:......:|::|...|::|||:.:|....|.:
 Worm   281 GLQTTILLSVCFFLTILSEMTPTTSEAVPLLGVFFSALTFIVAMSTTFTILVLNIRYRQITNHYL 345

  Fly   325 APWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPK--- 386
            :|..:.:|::.||..:.:|||.:.|....            .|..::.|:.|....|..|..
 Worm   346 SPMFRSIFLECLPWLMMMKRPDHKFRRGS------------SYRDSSADQCVQCAKNAELKSILR 398

  Fly   387 -EDLSQSITANG--PFGGS-----------------CQVHGPVPPLTHCSSDEIAAVPDMDIGPL 431
             .|..|.|..|.  ||...                 ||:|            |.|.......|.|
 Worm   399 GTDNQQQIETNTFYPFPTETLSLNRKVGDGLFIQRRCQIH------------EEARSEKFTHGML 451

  Fly   432 GMKSPILNNPAFSHSKCLPKIHK----SCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLW 492
            ..:..:..|.: ..:..|..|.|    ....|..|.:...::.....::::||:.|..:||..|.
 Worm   452 ACEKSLRENGS-ELANILVTILKMYEVMVSQVERIRKRIALKRKRKDIQDEWKFAAQAVDRFCLI 515

  Fly   493 IFTLAVVV 500
            |||:..::
 Worm   516 IFTIVFII 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	174/528 (33%)
		Neur_chan_LBD	12..227	CDD:280998	96/219 (44%)
		Neur_chan_memb	234..505	CDD:280999	73/295 (25%)
acr-7	NP_495647.1	LIC	28..524	CDD:273305	172/525 (33%)
		Neur_chan_LBD	31..247	CDD:280998	96/219 (44%)
		Neur_chan_memb	254..524	CDD:280999	73/295 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4952
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860