Protein Alignment nAChRalpha4 and unc-29

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_492399.1
• Gene: unc-29 / 172703
• WormBaseID: WBGene00006765
• Length: 493
• Species: Caenorhabditis elegans
• Alignment Length: 532
• Identity: 199/532 - (37%)
• Similarity: 304/532 - (57%)
• Gaps: 76/532 - (14%)

  Fly     1 MVHGAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDV-LKVCIKLKLSQLIDVNLKNQIMTTNLWV 64
            ::...:..:.|.:||..|:...||.|::||.|:::: |.|.:.|:|..||:|:.|:|:|.||:|:
 Worm    19 VIINTINASDDEERLMVDVFRGYNSLIQPVRNSSELPLIVKMALQLVLLINVDEKDQVMHTNVWL 83

  Fly    65 EQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPP 129
            ...|:|::::|.|..||.:..:.|..|.:|.|||||:||||||:||:......|..:|.:.|.||
 Worm    84 TLQWHDFQMKWNPVNYGEIKQIRVSPDKVWLPDIVLFNNADGNYEVSFMCNVVINHKGDMLWVPP 148

  Fly   130 AIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWD 194
            |||||||.||||:||||||.|.|.||||||:..::.|..        |.|..||:||:..|..||
 Worm   149 AIYKSSCIIDVEFFPFDEQVCTLVFGSWTYNENEIKLEF--------VQAELVDVSEYSASSIWD 205

  Fly   195 ILEVPA-VRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEK 258
            :::||| :.|::         ..|.|.:.:|||||||||.:|||.:.::||::..|:||:|||||
 Worm   206 VIDVPASLVNKR---------SRIEFQVRIRRKTLFYTVVLIIPTVLMAFLSMAVFFLPTDSGEK 261

  Fly   259 VTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHK 323
            :||:||:|:|:.||.|||.:|:||||..:||:.|||:...:|..|:|.|||:::||:||.|:||:
 Worm   262 ITLTISVLLSIVVFLLLVSKILPPTSSTIPLMAKYLLLTFVLNVITILVTVIIINVYFRGPRTHR 326

  Fly   324 MAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKED 388
            |..||:.||:.|||..:.:|||                               .|....|..:..
 Worm   327 MPQWVRVVFLQFLPKLVCMKRP-------------------------------KSASERSAVRSG 360

  Fly   389 LSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIH 453
            ::| :...|.|..|...|.|:.|    |:|:              ::..:.|.|.:.:.....:.
 Worm   361 MAQ-LPGVGQFTLSPSAHHPLCP----SADD--------------RTTTIRNTASNETSAYYPLS 406

  Fly   454 ----KSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYD 514
                ::...:.:|.||.|..|.....::|||||||::|||.|::|....|.||.||:..||.::.
 Worm   407 TDALRAIDAIEYITEHLKRDEQHKSFRDDWKYVAMIIDRLLLYVFFGITVGGTCGILFSAPHVFQ 471

  Fly   515 DRIPIIEQKDLD 526
               .|.:|:.||
 Worm   472 ---RIDQQEMLD 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	191/509 (38%)
		Neur_chan_LBD	12..227	CDD:280998	92/216 (43%)
		Neur_chan_memb	234..505	CDD:280999	91/274 (33%)
unc-29	NP_492399.1	LIC	6..466	CDD:273305	193/513 (38%)
		Neur_chan_LBD	30..230	CDD:280998	92/216 (43%)
		Neur_chan_memb	237..462	CDD:280999	91/274 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820