Protein Alignment nAChRalpha4 and Chrna2

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_596911.1
• Gene: Chrna2 / 170945
• RGDID: 621533
• Length: 511
• Species: Rattus norvegicus
• Alignment Length: 510
• Identity: 231/510 - (45%)
• Similarity: 308/510 - (60%)
• Gaps: 60/510 - (11%)

  Fly    14 RLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPK 78
            ||:..|...||:..|||.||:||:.|...|.::|||||:.|||:||||:|::|.|.||||||:|.
  Rat    38 RLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPA 102

  Fly    79 EYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYF 143
            |:|.|..|.|||:.||.|||||||||||.|.||..|||.::..|.|.|.|||||||||.|||.:|
  Rat   103 EFGNVTSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFF 167

  Fly   144 PFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYT 208
            |||:|.|.:||||||||..|:||..|:..         |||.:::.|.||.|:......|.|.|.
  Rat   168 PFDQQNCKMKFGSWTYDKAKIDLEQMERT---------VDLKDYWESGEWAIINATGTYNSKKYD 223

  Fly   209 CCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFF 273
            ||.|.|.|:|:...:||..||||:|:||||:.||.||||.|||||:.|||:||.||:|:||.||.
  Rat   224 CCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFL 288

  Fly   274 LLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPA 338
            ||:.||||.||||:||:|:||:|.||.|::||.:||.|||||.|||.||.|..||:...:..:|.
  Rat   289 LLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPR 353

  Fly   339 FLFIKRPTYNFE---TSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFG 400
            :|.:.||....|   :..|.|..::     ::..||:|    :|......:|:..:
  Rat   354 WLMMNRPLPPMELHGSPDLKLSPSY-----HWLETNMD----AGEREETEEEEEEE--------- 400

  Fly   401 GSCQVHGPVPPLTHCSSDE----IAAVPDMDIGPL----GM----KSPILNNPAFSHSKCL-PKI 452
                             ||    .|.:||..:|.|    |:    ..|....|:.:....| |:|
  Rat   401 -----------------DENICVCAGLPDSSMGVLYGHGGLHLRAMEPETKTPSQASEILLSPQI 448

  Fly   453 HKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIIL 507
            .|:...|.:||:..:.::..:.|||||||||||:||:|||:|.:...:||.|:.|
  Rat   449 QKALEGVHYIADRLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFL 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	229/506 (45%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	113/214 (53%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
Chrna2	NP_596911.1	LIC	35..504	CDD:455710	231/510 (45%)
		LGIC_ECD_nAChR_A2	36..242	CDD:349816	113/212 (53%)
		Cys-loop	160..174	CDD:349816	9/13 (69%)