DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha4 and HTR3C

DIOPT Version :9

Sequence 1:	NP_001097669.2	Gene:	nAChRalpha4 / 40521	FlyBaseID:	FBgn0266347	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_570126.2	Gene:	HTR3C / 170572	HGNCID:	24003	Length:	447	Species:	Homo sapiens

Alignment Length:	314	Identity:	87/314 - (27%)
Similarity:	160/314 - (50%)	Gaps:	18/314 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPKEYGGVHMLHVP 89
            |..||..|.:...:|.|...||.::.|:.:.|::|:.||::..|.:..:.|.|||..|::.|.|.
Human    52 KAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVL 116

  Fly    90 SDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKF 154
            ::::|.|||.:..:.|.: :......|.|.|||.:::..|....|.|.:|:.|||||:|.|...|
Human   117 AENLWLPDIFIVESMDVD-QTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTF 180

  Fly   155 GSWTYDGFKVD--LRHMDEQQGSNVVAVGVDLSEFYMSV--EWDILEVPAVRNEKFYTCCDEPYL 215
            .|:.|   .||  |..||::     |....|.|...:..  ||::|.:.....:  .:..:..|.
Human   181 SSFLY---TVDSMLLGMDKE-----VWEITDTSRKVIQTQGEWELLGINKATPK--MSMGNNLYD 235

  Fly   216 DITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLVVEII 280
            .|.|.:.:||:...|.:|:::|...:..:..|:||||::|..:....|::|:..:||.|::.:::
Human   236 QIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLL 300

  Fly   281 PPTSLVVPLLGKYLIFAMILVSISICVTV-VVLNVHFRSPQTHKMAPWVKRVFI 333
            |.:.  .||:..|....:.|:.:|:..|| :...:|..:.|...|..|:..:.:
Human   301 PASG--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLL 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	87/314 (28%)
		Neur_chan_LBD	12..227	CDD:280998	61/205 (30%)
		Neur_chan_memb	234..505	CDD:280999	24/101 (24%)
HTR3C	NP_570126.2	Neur_chan_LBD	43..445	CDD:332142	87/314 (28%)
HTR3C	NP_570126.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..405
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810