Protein Alignment nAChRalpha4 and nAChRalpha1

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_061502948.1
• Gene: nAChRalpha1 / 1272986
• VectorBaseID: AGAMI1_015142
• Length: 581
• Species: Anopheles gambiae
• Alignment Length: 484
• Identity: 274/484 - (56%)
• Similarity: 341/484 - (70%)
• Gaps: 40/484 - (8%)

  Fly     9 NPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKL 73
            |||:||||||||||||:|:|||.|.:|.|.|.:.|:|||||||||||||||||:||||.|.||||
Mosquito    21 NPDSKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKL 85

  Fly    74 RWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEI 138
            :|.|.:||||..|||||:|||.||||||||||||:|||:.|||.::..|.|.|||||||||.|||
Mosquito    86 KWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEI 150

  Fly   139 DVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRN 203
            ||||||||||||.:|||||||||:.|||||:.:...|:.:.:|:||.::|:||||||::||||||
Mosquito   151 DVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLQQTPDSDNIDIGIDLQDYYISVEWDIMKVPAVRN 215

  Fly   204 EKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILIS 268
            ||||:||:|||.||.||||:||||||||||:||||:|||||:||.||||||||||::|.||||:|
Mosquito   216 EKFYSCCEEPYPDIIFNITLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLS 280

  Fly   269 LHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFI 333
            |.|||||:.||||||||.||||||||:|.|:||::|:.||:.||||:||||.||:|||||.||||
Mosquito   281 LTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVHRVFI 345

  Fly   334 DFLPAFLFIKRP------------------TYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGY 380
            :.||..|.|:||                  |..|:....:.|....|...|.:..:|..|..|.:
Mosquito   346 ELLPKVLCIERPKKEDEPSDNDDQTPTDVLTDVFQVPPDVEKYVGFCGKEYGTDFDIPALPPSRF 410

  Fly   381 NNSLPKEDLSQSITANGPFGGSCQVHGPVP--PLTHCSSDEIAAVPDMDIGP--LGMKSPILNNP 441
            :           :.|:|.. |.|....|:|  ||.....|..:...:.|:.|  .|..||....|
Mosquito   411 D-----------VAASGGV-GPCFGEPPLPALPLPGGDDDLFSPTGNGDMSPTCCGDLSPTFEKP 463

  Fly   442 AFSHSKCLPKIHKSCFCVRFIAEHTKMQE 470
                  .|.::.|:....||:|:|.:.::
Mosquito   464 ------LLREMEKTIEASRFVAQHVRNKD 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	274/484 (57%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	156/217 (72%)
		Cys-loop	136..150	CDD:349832	13/13 (100%)
nAChRalpha1	XP_061502948.1	None