Protein Alignment nAChRalpha4 and nAChRalpha6

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_061502417.1
• Gene: nAChRalpha6 / 1269406
• VectorBaseID: AGAMI1_002766
• Length: 509
• Species: Anopheles gambiae
• Alignment Length: 531
• Identity: 196/531 - (36%)
• Similarity: 286/531 - (53%)
• Gaps: 82/531 - (15%)

  Fly    10 PDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMT--------------- 59
            |..|||.::||:.||.|.|||.|.:|.|:|...|.|.|:|||:.||||:|
Mosquito    26 PHEKRLLNNLLATYNTLERPVANESDPLEVKFGLTLQQIIDVDEKNQILTTNAWLNLDEKNQLLI 90

  Fly    60 TNLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLV 124
            ||:|:...|.||.|||...|||||..|.:..:.:|:||:::||:||..|:.|..|...:.:.|..
Mosquito    91 TNIWLSLEWNDYNLRWNDSEYGGVRDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKNNGSC 155

  Fly   125 EWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDL-RHMDEQQGSNVVAVGVDLSEFY 188
            .:.||.|:||:|:||:.:||||:|.|.:|||||||||.::|| .:.|:         |.|||:|.
Mosquito   156 LYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLILNSDD---------GGDLSDFI 211

  Fly   189 MSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPS 253
            .:.||.::.:|..:|...|.||.|||:||||.|.:||:||:|..|:|:||:.||.:.:|.|.||.
Mosquito   212 TNGEWYLIGMPGKKNTITYQCCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPP 276

  Fly   254 DSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRS 318
            |||||:||.::||:||.||..||.|.:|..|..:||||.|....|.:|:.|:.:||||||.|.|:
Mosquito   277 DSGEKLTLGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMVASSVVLTVVVLNYHHRT 341

  Fly   319 PQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNS 383
            ...|:|.||:|.||:.:||..|.:.||........::|                    |:.....
Mosquito   342 ADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTIIL--------------------SNRMKEL 386

  Fly   384 LPKEDLSQSITAN-------------GPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKS 435
            ..||..|:|:.||             |..|.:..:.|.|       ...:..|.:.::.
Mosquito   387 ELKERSSKSLLANVLDIDDDFRHPCSGISGSTTAIGGSV-------FTRLTTVEEQNVS------ 438

  Fly   436 PILNNPAFSHSKCLPK-IHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVV 499
                      |.|..| :|.....::||....|..::..::..|||:.|||:||..|::|||..:
Mosquito   439 ----------SGCSHKDLHHILKELQFITNRMKKADEEQELISDWKFAAMVVDRFCLFVFTLFTI 493

  Fly   500 VGTAGIILQAP 510
            :.|..::|.||
Mosquito   494 IATVTVLLSAP 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	193/524 (37%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	101/233 (43%)
		Cys-loop	136..150	CDD:349832	8/13 (62%)
nAChRalpha6	XP_061502417.1	None