DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha4 and CHRNG

DIOPT Version :9

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_005190.4 Gene:CHRNG / 1146 HGNCID:1967 Length:517 Species:Homo sapiens


Alignment Length:545 Identity:185/545 - (33%)
Similarity:277/545 - (50%) Gaps:95/545 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 GNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYK 72
            |....:||..||:.||:..:||....:||:.|.:||.|:.||.:|.:.:.:|||:|:|..|.||:
Human    22 GRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYR 86

  Fly    73 LRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCE 137
            |||:|::|.|:.:|.|||..:|||||||.||.||.|||.|.....:..:|.:.|.||||::|:|.
Human    87 LRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACS 151

  Fly   138 IDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVR 202
            |.|.|||||.|.|.|.|.|.||...::||: :.::.|..:..:.:|...|..:.||.|...||  
Human   152 ISVTYFPFDWQNCSLIFQSQTYSTNEIDLQ-LSQEDGQTIEWIFIDPEAFTENGEWAIQHRPA-- 213

  Fly   203 NEKFYTCCDEPYLD------------ITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDS 255
                     :..||            :.|.:.::||.|||.:|||.||:.||.:.:|..:||:.:
Human   214 ---------KMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKA 269

  Fly   256 -GEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSP 319
             |:|.|::|::|::..||..||.:.:|.||..|||:.|||.|.:::..:.:...||||||..|||
Human   270 GGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSP 334

  Fly   320 QTHKMAPWVKRVFIDFLPAFLFIK-RPTYNFETSKLLLKDTHACFYPYYSATNIDRLV--SSGYN 381
            .||.||..|::||:..||..|.:. ||     .:...::||.:            ||.  |||::
Human   335 HTHSMARGVRKVFLRLLPQLLRMHVRP-----LAPAAVQDTQS------------RLQNGSSGWS 382

  Fly   382 NS--------LPKEDL------SQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGP-L 431
            .:        ||:.:|      .|.:.|                         ||:..::.|| |
Human   383 ITTGEEVALCLPRSELLFQQWQRQGLVA-------------------------AALEKLEKGPEL 422

  Fly   432 GMKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRL-FLWIFT 495
            |     |:....|..:..|.|.........||.....|.......|:|..|..||||: ||.:.:
Human   423 G-----LSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAMLS 482

  Fly   496 LAVVVGTAGIILQAPTLYDDRIPII 520
            | .:.|||||.|.|   :.:|:|.:
Human   483 L-FICGTAGIFLMA---HYNRVPAL 503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:273305 179/528 (34%)
Neur_chan_LBD 12..227 CDD:280998 86/226 (38%)
Neur_chan_memb 234..505 CDD:280999 87/290 (30%)
CHRNGNP_005190.4 LGIC_ECD_nAChR_G 49..241 CDD:349830 78/203 (38%)
Neur_chan_memb 248..492 CDD:397193 88/291 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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