Protein Alignment nAChRalpha4 and CHRNE

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_000071.1
• Gene: CHRNE / 1145
• HGNCID: 1966
• Length: 493
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 168/538 - (31%)
• Similarity: 261/538 - (48%)
• Gaps: 78/538 - (14%)

  Fly     4 GAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSW 68
            |...|..:..|||..|.:||:...|||....|.:.:.:|:.|:.||.:|.|.:.:||::|:...|
Human    16 GRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDW 80

  Fly    69 YDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYK 133
            .||:|.:...::||:..|.|||:.:|.|:|||.||.||.|.|.......:|..|.|.|.|||||:
Human    81 QDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYR 145

  Fly   134 SSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEV 198
            |.|.::|.|||||.|.|.|.|.|.||:..:|:.....:..|..:..:.:|...:..:.||.|...
Human   146 SVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFC 210

  Fly   199 PAVRNEKFYTCCDEP-YLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDS-GEKVTL 261
            |.|.........|.| ..|:.:::.:|||.|||.:|||:||:.||.|.:|.::||:.: |:|.|:
Human   211 PGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTV 275

  Fly   262 SISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAP 326
            ||::|::..||..|:.:.||.|||.|||||::|||.|::.::.:...|:||||..|:|.||.|:|
Human   276 SINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSP 340

  Fly   327 WVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQ 391
            .::.|.::.||..|....|           .:......|...|:::..|:.:  ...:.|:..|:
Human   341 RLRHVLLELLPRLLGSPPP-----------PEAPRAASPPRRASSVGLLLRA--EELILKKPRSE 392

  Fly   392 SITANGPFGGS-----------CQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSH 445
            .:     |.|.           ||..|...|...|..|
Human   393 LV-----FEGQRHRQGTWTAAFCQSLGAAAPEVRCCVD--------------------------- 425

  Fly   446 SKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAP 510
                        .|.|:||.|:.||.:.:...||..:...||.:..|...:...||::.|.|.|
Human   426 ------------AVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGA- 477

  Fly   511 TLYDDRIPIIEQKDLDFS 528
              |.:|:|     ||.::
Human   478 --YFNRVP-----DLPYA 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	160/513 (31%)
		Neur_chan_LBD	12..227	CDD:280998	77/215 (36%)
		Neur_chan_memb	234..505	CDD:280999	76/282 (27%)
CHRNE	NP_000071.1	LIC	21..475	CDD:273305	159/510 (31%)
		Neur_chan_LBD	24..240	CDD:280998	77/215 (36%)
		Neur_chan_memb	247..474	CDD:280999	76/283 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910