Protein Alignment nAChRalpha4 and Chrng

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_006529141.1
• Gene: Chrng / 11449
• MGIID: 87895
• Length: 541
• Species: Mus musculus
• Alignment Length: 536
• Identity: 184/536 - (34%)
• Similarity: 283/536 - (52%)
• Gaps: 51/536 - (9%)

  Fly     2 VHGAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQ 66
            |.||.:.|.: :||..||:.||:..:||....:||:.|.:||.|:.||.:|.:.:.:|||:|:|.
Mouse    39 VAGAQSRNQE-ERLLADLMRNYDPHLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEM 102

  Fly    67 SWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAI 131
            .|.||:|||:||:|.|:.:|.|||..:|||||||.||.||.|||.|.....:..:|.:.|.||||
Mouse   103 QWCDYRLRWDPKDYEGLWILRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAI 167

  Fly   132 YKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDIL 196
            ::|||.|.|.|||||.|.|.|.|.|.||...:::|: :.::.|..:..:.:|...|..:.||.|.
Mouse   168 FRSSCSISVTYFPFDWQNCSLVFQSQTYSTSEINLQ-LSQEDGQAIEWIFIDPEAFTENGEWAIR 231

  Fly   197 EVPAVRNEKFYTCCDEP-YLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDS-GEKV 259
            ..||..........:|. :..:.|.:.::||.|||.:|||.||:.||.:.:|.::||:.: |:|.
Mouse   232 HRPAKMLLDSVAPAEEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIYFLPAKAGGQKC 296

  Fly   260 TLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKM 324
            |::.::|::..||..||.:.:|.||..|||:.|||.|.|::..:.:..:||||||..|||.||.|
Mouse   297 TVATNVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLRSPHTHSM 361

  Fly   325 APWVKRVFIDFLPAFLFIK-RP--TYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPK 386
            |..|::||:..||..|.:. ||  ....:.::..|::..:..:|..:....|.        .||:
Mouse   362 ARGVRKVFLRLLPQLLRMHVRPLAPAAVQDARFRLQNGSSSGWPIMAREEGDL--------CLPR 418

  Fly   387 EDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAF--SHSKCL 449
            .:|         .....|.:|.|.          |.:..::.||     .:..:..|  |..:..
Mouse   419 SEL---------LFRQRQRNGLVQ----------AVLEKLENGP-----EVRQSQEFCGSLKQAS 459

  Fly   450 PKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRL-FLWIFTLAVVVGTAGIILQAPTLY 513
            |.|.........:|...:.|.......|:|..|..||||: ||.:.:| .:.|||||.|.|   :
Mouse   460 PAIQACVDACNLMARARRQQSHFDSGNEEWLLVGRVLDRVCFLAMLSL-FICGTAGIFLMA---H 520

  Fly   514 DDRIPIIEQKDLDFSG 529
            .:::|     ||.|.|
Mouse   521 YNQVP-----DLPFPG 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	175/510 (34%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	87/218 (40%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
Chrng	XP_006529141.1	LGIC_ECD_nAChR_G	71..263	CDD:349830	78/192 (41%)
		Cys-loop	172..186	CDD:349830	9/13 (69%)
		Neur_chan_memb	270..516	CDD:460753	81/278 (29%)