Protein Alignment nAChRalpha4 and Chrnb2

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_033732.2
• Gene: Chrnb2 / 11444
• MGIID: 87891
• Length: 501
• Species: Mus musculus
• Alignment Length: 514
• Identity: 216/514 - (42%)
• Similarity: 300/514 - (58%)
• Gaps: 68/514 - (13%)

  Fly     6 VAGNPDAKRLYDDLL--SNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSW 68
            |.|....:||.:.||  |.||||:||..|.::::.|.:.:.|:|||.|:.:.||||||:|:.|.|
Mouse    23 VLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEW 87

  Fly    69 YDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYK 133
            .||:|.|:|:::..:..:.:||.|||.||:||||||||.:||:..:.|.:..:|.:.|.||||||
Mouse    88 EDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYK 152

  Fly   134 SSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGV-DLSEFYMSVEWDILE 197
            |:|:|:|::||||:|.|.:||.|||||..::||          |:...| .|.:|..|.||||:.
Mouse   153 SACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDL----------VLKSDVASLDDFTPSGEWDIIA 207

  Fly   198 VPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLS 262
            :|..|||   ...|..|:|||::..:|||.||||:|:||||:.|:.|.:|.||||||.|||:||.
Mouse   208 LPGRRNE---NPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLC 269

  Fly   263 ISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPW 327
            ||:|::|.||.||:.:|:|||||.|||:||||:|.|:||:.||..:|.|||||.|||.||.||||
Mouse   270 ISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPW 334

  Fly   328 VKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQS 392
            ||.||::.||..||:::|.:.....:|.|:                       .....:|.....
Mouse   335 VKVVFLEKLPTLLFLQQPRHRCARQRLRLR-----------------------RRQREREGAGTL 376

  Fly   393 ITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMK--------SPILNNPAFSHSKCL 449
            ....||....|...                     :.|..|:        .|.......|...|.
Mouse   377 FFREGPAADPCTCF---------------------VNPASMQGLAGAFQAEPAAAGLGRSMGPCS 420

  Fly   450 PKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQ 508
            ..:.::...|||||:|.:.::|...|:|||||||||:||||||||....|.||.|:.||
Mouse   421 CGLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	213/509 (42%)
		Neur_chan_LBD	12..227	CDD:280998	97/217 (45%)
		Neur_chan_memb	234..505	CDD:280999	108/278 (39%)
Chrnb2	NP_033732.2	LIC	29..478	CDD:273305	212/505 (42%)
		Neur_chan_LBD	29..234	CDD:280998	97/217 (45%)
		Neur_chan_memb	241..477	CDD:280999	109/279 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm11113
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820