DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha4 and Chrna1

DIOPT Version :9

Sequence 1:	NP_001097669.2	Gene:	nAChRalpha4 / 40521	FlyBaseID:	FBgn0266347	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_031415.2	Gene:	Chrna1 / 11435	MGIID:	87885	Length:	457	Species:	Mus musculus

Alignment Length:	507	Identity:	206/507 - (40%)
Similarity:	294/507 - (57%)	Gaps:	82/507 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSW 68
            |.|.|:....||...|..:|:.:||||.:..::::|.:.|:|.|||:|:..|||:|||:.::|.|
Mouse    16 GLVLGSEHETRLVAKLFEDYSSVVRPVEDHREIVQVTVGLQLIQLINVDEVNQIVTTNVRLKQQW 80

  Fly    69 YDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYK 133
            .||.|:|.|.:||||..:|:||:.|||||:||||||||:|.:...||..:...|.:.|.||||:|
Mouse    81 VDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVLLDYTGHITWTPPAIFK 145

  Fly   134 SSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEV 198
            |.|||.|.:||||||.|.:|.|:|||||..|.:....:|.         |||.|..|.||.|.|.
Mouse   146 SYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQP---------DLSNFMESGEWVIKEA 201

  Fly   199 PAVRNEKFYTCC-DEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLS 262
            ...::..||:|| ..||||||::..|:|..|::.||:||||:..||||.|.||||:|||||:|||
Mouse   202 RGWKHWVFYSCCPTTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLPTDSGEKMTLS 266

  Fly   263 ISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPW 327
            ||:|:||.||.|::||:||.||..|||:|||::|.|:.|..||.:||:|:|.|.|||.||.|..|
Mouse   267 ISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHIMPEW 331

  Fly   328 VKRVFIDFLPAFLF---IKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDL 389
            |::||||.:|..:|   :|||:.:.:..::..:|.                            |:
Mouse   332 VRKVFIDTIPNIMFFSTMKRPSRDKQEKRIFTEDI----------------------------DI 368

  Fly   390 SQSITANGPFGGSCQVHG-PVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIH 453
            |             .:.| |.||                  |:|..||::.:         |::.
Mouse   369 S-------------DISGKPGPP------------------PMGFHSPLIKH---------PEVK 393

  Fly   454 KSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGI 505
            .:...|::|||..|..::|....|:|||||||:|.:.|.:|.|..::||..:
Mouse   394 SAIEGVKYIAETMKSDQESNNAAEEWKYVAMVMDHILLGVFMLVCLIGTLAV 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	206/505 (41%)
		Neur_chan_LBD	12..227	CDD:280998	100/215 (47%)
		Neur_chan_memb	234..505	CDD:280999	100/274 (36%)
Chrna1	NP_031415.2	Neur_chan_LBD	24..231	CDD:308532	100/215 (47%)
Chrna1	NP_031415.2	Neur_chan_memb	238..446	CDD:308533	100/276 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920