Protein Alignment nAChRalpha4 and CHRNB4

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_000741.1
• Gene: CHRNB4 / 1143
• HGNCID: 1964
• Length: 498
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 223/525 - (42%)
• Similarity: 311/525 - (59%)
• Gaps: 67/525 - (12%)

  Fly    13 KRLYDDLL--SNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRW 75
            ::|.||||  :.||.|:||..:::.::.:.::|.|:|||.||.:.||||||:|::|.|.||:|.|
Human    28 EKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTW 92

  Fly    76 EPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDV 140
            ....|.||::|.:|:..||.|||||||||||.:||::.|...:.|.|.|.|.|||||||:|:|:|
Human    93 NSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEV 157

  Fly   141 EYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVR--N 203
            :|||||:|.|.|||.|||||..::|:..|...         ..:.:|..|.||||:.:|..|  |
Human   158 KYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPT---------ASMDDFTPSGEWDIVALPGRRTVN 213

  Fly   204 EKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILIS 268
            .:     |..|:|:|::..::||.||||:|:||||:..:.|.:|.||||||.|||:||.||:|::
Human   214 PQ-----DPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVLLA 273

  Fly   269 LHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFI 333
            |..|.||:.:|:|||||.|||:||||:|.|:||:.||..:|.|||||.|||.||.|||||||.|:
Human   274 LTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFL 338

  Fly   334 DFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSL----PKEDLSQSIT 394
            ..||.|||:|||..:...::...........|..:||:..  .|:.|.||:    |....|:|
Human   339 HKLPTFLFMKRPGPDSSPARAFPPSKSCVTKPEATATSTS--PSNFYGNSMYFVNPASAASKS-- 399

  Fly   395 ANGPFGGSCQVHGPVPPLTHCSSDEIAAVP-DMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFC 458
               |.|.:     ||            |:| |..:.              |..:....:.::...
Human   400 ---PAGST-----PV------------AIPRDFWLR--------------SSGRFRQDVQEALEG 430

  Fly   459 VRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYDDRI----PI 519
            |.|||:|.|..::...|.|||||||||:||||||:|....|:||.|:.|  |.|:....    |.
Human   431 VSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFL--PPLFQTHAASEGPY 493

  Fly   520 IEQKD 524
            ..|:|
Human   494 AAQRD 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	216/500 (43%)
		Neur_chan_LBD	12..227	CDD:280998	96/217 (44%)
		Neur_chan_memb	234..505	CDD:280999	114/275 (41%)
CHRNB4	NP_000741.1	Neur_chan_LBD	5..480	CDD:332142	218/505 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..377		3/19 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8639
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820