Protein Alignment nAChRalpha4 and CHRNA7

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001177384.1
• Gene: CHRNA7 / 1139
• HGNCID: 1960
• Length: 531
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 205/556 - (36%)
• Similarity: 300/556 - (53%)
• Gaps: 68/556 - (12%)

  Fly     1 MVHGAVAGNPDA----------------------------KRLYDDLLSNYNKLVRPVVNTTDVL 37
            ::||....:|.:                            ::||.:|:.|||.|.|||.|.:..|
Human    16 LLHGKATASPPSTPPWDPGHIPGASVRPAPGPVSLQGEFQRKLYKELVKNYNPLERPVANDSQPL 80

  Fly    38 KVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYN 102
            .|...|.|.|::||:.|||::|||:|::.||.|:.|:|...||.||..:..|...||:|||:|||
Human    81 TVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYN 145

  Fly   103 NADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLR 167
            :||..|:.|..|...:.|.|..::.||.|:||||.|||.:||||.|.|.||||||:|.|:.:||:
Human   146 SADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQ 210

  Fly   168 HMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTV 232
             |.|          .|:|.:..:.|||::.:|..|:|:||.||.|||.|:||.:||||:||:|.:
Human   211 -MQE----------ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGL 264

  Fly   233 NIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFA 297
            |::|||:.||.|.:|.|.||:|||||::|.|::|:||.||.|||.||:|.||..|||:.:|....
Human   265 NLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST 329

  Fly   298 MILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHAC 362
            ||:|.:|:.|||:||..|...|...||..|.:.:.:::...||.:|||..:        |...||
Human   330 MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGED--------KVRPAC 386

  Fly   363 FYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMD 427
            .:.....:    |.|...:...|....:.::...| |.|...||....|.:......:|..|..|
Human   387 QHKQRRCS----LASVEMSAVAPPPASNGNLLYIG-FRGLDGVHCVPTPDSGVVCGRMACSPTHD 446

  Fly   428 IGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLW 492
            ...|....|...:|.      |.||.:.   ||:||...:.|::|..|..:||:.|.|:|||.|.
Human   447 EHLLHGGQPPEGDPD------LAKILEE---VRYIANRFRCQDESEAVCSEWKFAACVVDRLCLM 502

  Fly   493 IFTLAVVVGTAGIILQAPTLYDDRIPIIEQKDLDFS 528
            .|::..::.|.||::.||.       .:|....||:
Human   503 AFSVFTIICTIGILMSAPN-------FVEAVSKDFA 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	198/531 (37%)
		Neur_chan_LBD	12..227	CDD:280998	100/242 (41%)
		Neur_chan_memb	234..505	CDD:280999	91/270 (34%)
CHRNA7	NP_001177384.1	LIC	3..519	CDD:273305	200/535 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910