Protein Alignment nAChRalpha4 and CHRNA7

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001177384.1
• Gene: CHRNA7 / 1139
• HGNCID: 1960
• Length: 531
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 205/556 - (36%)
• Similarity: 300/556 - (53%)
• Gaps: 68/556 - (12%)

  Fly     1 MVHGAVAGNPDA----------------------------KRLYDDLLSNYNKLVRPVVNTTDVL 37
            ::||....:|.:                            ::||.:|:.|||.|.|||.|.:..|
Human    16 LLHGKATASPPSTPPWDPGHIPGASVRPAPGPVSLQGEFQRKLYKELVKNYNPLERPVANDSQPL 80

  Fly    38 KVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYN 102
            .|...|.|.|::||:.|||::|||:|::.||.|:.|:|...||.||..:..|...||:|||:|||
Human    81 TVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYN 145

  Fly   103 NADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLR 167
            :||..|:.|..|...:.|.|..::.||.|:||||.|||.:||||.|.|.||||||:|.|:.:||:
Human   146 SADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQ 210

  Fly   168 HMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTV 232
             |.|          .|:|.:..:.|||::.:|..|:|:||.||.|||.|:||.:||||:||:|.:
Human   211 -MQE----------ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGL 264

  Fly   233 NIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFA 297
            |::|||:.||.|.:|.|.||:|||||::|.|::|:||.||.|||.||:|.||..|||:.:|....
Human   265 NLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST 329

  Fly   298 MILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHAC 362
            ||:|.:|:.|||:||..|...|...||..|.:.:.:::...||.:|||..:        |...||
Human   330 MIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGED--------KVRPAC 386

  Fly   363 FYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMD 427
            .:.....:    |.|...:...|....:.::...| |.|...||....|.:......:|..|..|
Human   387 QHKQRRCS----LASVEMSAVAPPPASNGNLLYIG-FRGLDGVHCVPTPDSGVVCGRMACSPTHD 446

  Fly   428 IGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLW 492
            ...|....|...:|.      |.||.:.   ||:||...:.|::|..|..:||:.|.|:|||.|.
Human   447 EHLLHGGQPPEGDPD------LAKILEE---VRYIANRFRCQDESEAVCSEWKFAACVVDRLCLM 502

  Fly   493 IFTLAVVVGTAGIILQAPTLYDDRIPIIEQKDLDFS 528
            .|::..::.|.||::.||.       .:|....||:
Human   503 AFSVFTIICTIGILMSAPN-------FVEAVSKDFA 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	198/531 (37%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	101/245 (41%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
CHRNA7	NP_001177384.1	LIC	3..519	CDD:273305	200/535 (37%)