DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha4 and CHRNA2

DIOPT Version :9

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_000733.2 Gene:CHRNA2 / 1135 HGNCID:1956 Length:529 Species:Homo sapiens


Alignment Length:499 Identity:230/499 - (46%)
Similarity:306/499 - (61%) Gaps:43/499 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 RLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPK 78
            ||:..|...||:..|||.||:||:.|...|.::|||||:.|||:||||:|::|.|.||||||.|.
Human    61 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPT 125

  Fly    79 EYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYF 143
            ::|.:..|.|||:.||.|||||||||||.|.||..|||.::|.|.|.|.|||||||||.|||.:|
Human   126 DFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFF 190

  Fly   144 PFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYT 208
            |||:|.|.:||||||||..|:||..|::.         |||.:::.|.||.|:......|.|.|.
Human   191 PFDQQNCKMKFGSWTYDKAKIDLEQMEQT---------VDLKDYWESGEWAIVNATGTYNSKKYD 246

  Fly   209 CCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFF 273
            ||.|.|.|:|:...:||..||||:|:||||:.||.||||.||||||.|||:||.||:|:||.||.
Human   247 CCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFL 311

  Fly   274 LLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPA 338
            ||:.||||.||||:||:|:||:|.||.|::||.:||.|||||.|||.||.|..||:...:..:|.
Human   312 LLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPR 376

  Fly   339 FLFIKRPTYNFETS---KLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFG 400
            :|.:.||....|..   :|.|..::     ::..:|:|   :......:.:||.........|..
Human   377 WLLMNRPPPPVELCHPLRLKLSPSY-----HWLESNVD---AEEREVVVEEEDRWACAGHVAPSV 433

  Fly   401 GSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCL--PKIHKSCFCVRFIA 463
            |:...||      |..|           |..|.|:..|    ....:.|  |.:.|:...|.:||
Human   434 GTLCSHG------HLHS-----------GASGPKAEAL----LQEGELLLSPHMQKALEGVHYIA 477

  Fly   464 EHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIIL 507
            :|.:.::..:.|||||||||||:||:|||:|.:...:||.|:.|
Human   478 DHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFL 521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:273305 228/495 (46%)
Neur_chan_LBD 12..227 CDD:280998 112/212 (53%)
Neur_chan_memb 234..505 CDD:280999 111/275 (40%)
CHRNA2NP_000733.2 LIC 57..522 CDD:273305 230/499 (46%)
Neur_chan_LBD 59..265 CDD:280998 112/212 (53%)
Neur_chan_memb 272..520 CDD:280999 112/276 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 251 1.000 Domainoid score I2107
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 485 1.000 Inparanoid score I1448
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45250
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm8639
orthoMCL 1 0.900 - - OOG6_101158
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2381
SonicParanoid 1 1.000 - - X294
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.810

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