Protein Alignment nAChRalpha4 and CHRNA2

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_000733.2
• Gene: CHRNA2 / 1135
• HGNCID: 1956
• Length: 529
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 230/499 - (46%)
• Similarity: 306/499 - (61%)
• Gaps: 43/499 - (8%)

  Fly    14 RLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPK 78
            ||:..|...||:..|||.||:||:.|...|.::|||||:.|||:||||:|::|.|.||||||.|.
Human    61 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPT 125

  Fly    79 EYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYF 143
            ::|.:..|.|||:.||.|||||||||||.|.||..|||.::|.|.|.|.|||||||||.|||.:|
Human   126 DFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFF 190

  Fly   144 PFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYT 208
            |||:|.|.:||||||||..|:||..|::.         |||.:::.|.||.|:......|.|.|.
Human   191 PFDQQNCKMKFGSWTYDKAKIDLEQMEQT---------VDLKDYWESGEWAIVNATGTYNSKKYD 246

  Fly   209 CCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFF 273
            ||.|.|.|:|:...:||..||||:|:||||:.||.||||.||||||.|||:||.||:|:||.||.
Human   247 CCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFL 311

  Fly   274 LLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPA 338
            ||:.||||.||||:||:|:||:|.||.|::||.:||.|||||.|||.||.|..||:...:..:|.
Human   312 LLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPR 376

  Fly   339 FLFIKRPTYNFETS---KLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFG 400
            :|.:.||....|..   :|.|..::     ::..:|:|   :......:.:||.........|..
Human   377 WLLMNRPPPPVELCHPLRLKLSPSY-----HWLESNVD---AEEREVVVEEEDRWACAGHVAPSV 433

  Fly   401 GSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCL--PKIHKSCFCVRFIA 463
            |:...||      |..|           |..|.|:..|    ....:.|  |.:.|:...|.:||
Human   434 GTLCSHG------HLHS-----------GASGPKAEAL----LQEGELLLSPHMQKALEGVHYIA 477

  Fly   464 EHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIIL 507
            :|.:.::..:.|||||||||||:||:|||:|.:...:||.|:.|
Human   478 DHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFL 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	228/495 (46%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	112/214 (52%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
CHRNA2	NP_000733.2	Atrophin-1	<28..>75	CDD:460830	5/13 (38%)
		LIC	57..522	CDD:455710	230/499 (46%)
		LGIC_ECD_nAChR_A2	59..265	CDD:349816	112/212 (53%)
		Cys-loop	183..197	CDD:349816	9/13 (69%)