Protein Alignment nAChRalpha4 and CHRNA1

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_016858745.1
• Gene: CHRNA1 / 1134
• HGNCID: 1955
• Length: 489
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 206/532 - (38%)
• Similarity: 291/532 - (54%)
• Gaps: 107/532 - (20%)

  Fly     4 GAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQ-- 66
            |.|.|:....||...|..:|:.:||||.:...|::|.:.|:|.|||:|:..|||:|||:.::|
Human    23 GLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGD 87

  Fly    67 -----------------------SWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNF 108
                                   .|.||.|:|.|.:||||..:|:||:.|||||:||||||||:|
Human    88 MVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDF 152

  Fly   109 EVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQ 173
            .:...||..:...|.:.|.||||:||.|||.|.:||||||.|.:|.|:|||||..|.:....:|.
Human   153 AIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQP 217

  Fly   174 GSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYTCC-DEPYLDITFNITMRRKTLFYTVNIIIP 237
                     |||.|..|.||.|.|....::...|:|| |.||||||::..|:|..|::.||:|||
Human   218 ---------DLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIP 273

  Fly   238 CMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVS 302
            |:..||||.|.||||:|||||:|||||:|:||.||.|::||:||.||..|||:|||::|.|:.|.
Human   274 CLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVI 338

  Fly   303 ISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPAFLF---IKRPTYNFETSKLLLKDTHACFY 364
            .||.:||:|:|.|.|||.||.|..||::||||.:|..:|   :|||:...:..|:..:|.
Human   339 ASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDI----- 398

  Fly   365 PYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFGGSCQVHG-PVPPLTHCSSDEIAAVPDMDI 428
                                   |:|             .:.| |.||
Human   399 -----------------------DIS-------------DISGKPGPP----------------- 410

  Fly   429 GPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWI 493
             |:|..||::.:         |::..:...:::|||..|..::|.....:|||||||:|.:.|.:
Human   411 -PMGFHSPLIKH---------PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGV 465

  Fly   494 FTLAVVVGTAGI 505
            |.|..::||..:
Human   466 FMLVCIIGTLAV 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	206/530 (39%)
		Neur_chan_LBD	12..227	CDD:280998	101/240 (42%)
		Neur_chan_memb	234..505	CDD:280999	99/274 (36%)
CHRNA1	XP_016858745.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920