DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha4 and Chrna2

DIOPT Version :9

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_659052.1 Gene:Chrna2 / 110902 MGIID:87886 Length:512 Species:Mus musculus


Alignment Length:506 Identity:232/506 - (45%)
Similarity:308/506 - (60%) Gaps:51/506 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 RLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPK 78
            ||:..|...||:..|||.||:||:.|...|.::|||||:.|||:||||:|::|.|.||||||:|.
Mouse    38 RLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPA 102

  Fly    79 EYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYF 143
            |:|.:..|.|||:.||.|||||||||||.|.||..|||.::..|.|.|.|||||||||.|||.:|
Mouse   103 EFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFF 167

  Fly   144 PFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFYT 208
            |||:|.|.:||||||||..|:||..|:..         |||.:::.|.||.|:......|.|.|.
Mouse   168 PFDQQNCKMKFGSWTYDKAKIDLEQMERT---------VDLKDYWESGEWAIINATGTYNSKKYD 223

  Fly   209 CCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVFF 273
            ||.|.|.|:|:...:||..||||:|:||||:.||.||||.|||||:.|||:||.||:|:||.||.
Mouse   224 CCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFL 288

  Fly   274 LLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLPA 338
            ||:.||||.||||:||:|:||:|.||.|::||.:||.|||||.|||.||.|..||:...:..:|.
Mouse   289 LLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPR 353

  Fly   339 FLFIKRPTYNFE---TSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFG 400
            :|.:.||....|   :..|.|..|:     ::..||:|     .......:|:..:....|    
Mouse   354 WLMMNRPLPPMELHGSPGLKLSPTY-----HWLETNMD-----AEEREETEEEEEEEEDEN---- 404

  Fly   401 GSCQVHGPVPPLTHCSSDEIAAVPDMDIGPL-GMKS-------PILNNPAFSHSKCL-PKIHKSC 456
                       :..|     |.:||..:|.| |..|       |....|:.:....| |:|.|:.
Mouse   405 -----------ICMC-----AGLPDSSMGVLYGHGSLHLRAMGPEAKTPSQASEILLSPQIQKAL 453

  Fly   457 FCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIIL 507
            ..|.:||:|.:.::..:.|||||||||||:||:|||:|.:...:||.|:.|
Mouse   454 EGVHYIADHLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFL 504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:273305 230/502 (46%)
Neur_chan_LBD 12..227 CDD:280998 112/212 (53%)
Neur_chan_memb 234..505 CDD:280999 113/282 (40%)
Chrna2NP_659052.1 LIC 15..505 CDD:273305 232/506 (46%)
LGIC_ECD_nAChR_A2 36..242 CDD:349816 112/212 (53%)
Cys-loop 160..174 CDD:349816 9/13 (69%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 253 1.000 Domainoid score I2060
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 476 1.000 Inparanoid score I1470
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45250
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm8871
orthoMCL 1 0.900 - - OOG6_101158
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2381
SonicParanoid 1 1.000 - - X294
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.810

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