DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha4 and Chrna5

DIOPT Version :9

Sequence 1:	NP_001097669.2	Gene:	nAChRalpha4 / 40521	FlyBaseID:	FBgn0266347	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001360830.1	Gene:	Chrna5 / 110835	MGIID:	87889	Length:	467	Species:	Mus musculus

Alignment Length:	518	Identity:	204/518 - (39%)
Similarity:	289/518 - (55%)	Gaps:	106/518 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GAVAGNPD----AKR---LYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTN 61
            ||..|.|:    ||.   |:.||..:|.|.||||.:.:|.:|:...|.:|||:||:.|||:||||
Mouse    32 GARGGLPELSSAAKHEDSLFRDLFEDYEKWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTN 96

  Fly    62 LWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEW 126
            :|::|.|.|.||||.|.:|||:.::.||||.:|.|||||::||||.|| ..:||..:...|.|.|
Mouse    97 VWLKQEWIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFE-GASTKTVVRYNGTVTW 160

  Fly   127 KPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSV 191
            ..||.|||||.|||.:||||.|.|.:|||||||||.:||:...|:.         ||.::|:.:.
Mouse   161 TQPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQD---------VDRTDFFDNG 216

  Fly   192 EWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSG 256
            ||:|:.....:..:..:||..|.  ||::..::|..||||:.:||||:|:|||||:.|||||:.|
Mouse   217 EWEIMSAMGSKGNRTDSCCWYPC--ITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEG 279

  Fly   257 EKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQT 321
            ||::|..|:|:||.||.|::.||||.:|.|:||:|:||:|.||.|::||.|||..:|:|.||..|
Mouse   280 EKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSST 344

  Fly   322 HK-MAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLP 385
            |. |||||:::|:..||               |||...:||           ||..:.
Mouse   345 HNAMAPWVRKIFLHKLP---------------KLLCMRSHA-----------DRYFTQ------- 376

  Fly   386 KEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLP 450
            :|:                                   .:.|.||                |...
Mouse   377 REE-----------------------------------AEKDGGP----------------KSRN 390

  Fly   451 KIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLY 513
            .:..:..|:|:|..|...:.|..:|.||||::|.||||:|||.|.|..::||.|:.:  |.:|
Mouse   391 TLEAALDCIRYITRHVVKENDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGLFV--PVIY 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	201/508 (40%)
		Neur_chan_LBD	12..227	CDD:280998	99/217 (46%)
		Neur_chan_memb	234..505	CDD:280999	94/271 (35%)
Chrna5	NP_001360830.1	LGIC_ECD	45..251	CDD:355788	98/217 (45%)
Chrna5	NP_001360830.1	Neur_chan_memb	257..445	CDD:367256	94/271 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2060
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830