Protein Alignment nAChRalpha4 and chrna3l

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_031754974.1
• Gene: chrna3l / 101732933
• XenbaseID: XB-GENE-29086591
• Length: 498
• Species: Xenopus tropicalis
• Alignment Length: 518
• Identity: 230/518 - (44%)
• Similarity: 311/518 - (60%)
• Gaps: 74/518 - (14%)

  Fly    14 RLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPK 78
            |||:|||.:||..:|||:|.:|.:.:..::.:|||:.|:..||||.||||:...|.||||:|.|.
 Frog    39 RLYEDLLKSYNPYIRPVMNVSDPVILHFEVSMSQLVKVDEVNQIMETNLWLRHLWNDYKLKWNPS 103

  Fly    79 EYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYF 143
            :|||:..|.:|:..||||||||||||.|.|.|....||.:...|.|.|.||||:||||:|||.:|
 Frog   104 DYGGIEFLRIPASQIWRPDIVLYNNAVGAFHVDDKAKAVVRYSGDVTWIPPAIFKSSCKIDVTFF 168

  Fly   144 PFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVG--VDLSEFYMSVEWDILEVPAVRNEKF 206
            |||.|.|.|||||||||..|:           |:|.:|  ::|.||:.|.||.|:..|..::|..
 Frog   169 PFDYQNCSLKFGSWTYDKAKI-----------NLVMIGSKINLKEFWESGEWVIINAPGYKHEIK 222

  Fly   207 YTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHV 271
            |.||.|.|.|||:::.:||..||||:.|||||:.||.||:|.||||||.||||||.:|:|:||.|
 Frog   223 YNCCVEIYQDITYSLYIRRLPLFYTIYIIIPCLLISCLTILVFYLPSDCGEKVTLCMSVLLSLTV 287

  Fly   272 FFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFL 336
            |.|::.||||.||||:||:|:||:|.||.|::||.:||.|||||:|:|:||.|..||||.|:..|
 Frog   288 FLLVITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKTHTMPHWVKRFFLHLL 352

  Fly   337 PAFLFIKRPTYNFETSKLLLK----------DTHAC----FYPYYSATNIDRLVSSGYNNSLPKE 387
            |..:|:.||    |.....||          :..:|    ||.       |...:.|....|...
 Frog   353 PKVMFMTRP----EKQPYALKPQAYLDISSSEIRSCQDQLFYQ-------DSSCACGQLKRLYTS 406

  Fly   388 DLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKI 452
            |.:.::|.    |.|.:                               .:.|....|.|...|:|
 Frog   407 DTACNVTR----GSSLE-------------------------------SMYNLGLHSGSGLSPEI 436

  Fly   453 HKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYDD 515
            .::...|.||||:.|.|:::.:|::||||||||:||:|||:|.|..::||||:.|| |.|:.|
 Frog   437 REAIEDVHFIAENMKAQDEAKEVQDDWKYVAMVIDRIFLWVFVLVCILGTAGLFLQ-PLLFSD 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	224/506 (44%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	106/216 (49%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
chrna3l	XP_031754974.1	LIC	34..491	CDD:455710	225/508 (44%)
		LGIC_ECD_nAChR_A3	37..243	CDD:349817	106/214 (50%)
		Cys-loop	161..175	CDD:349817	9/13 (69%)