Protein Alignment nAChRalpha4 and chrng

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001241879.1
• Gene: chrng / 100536659
• ZFINID: ZDB-GENE-030131-3805
• Length: 540
• Species: Danio rerio
• Alignment Length: 535
• Identity: 185/535 - (34%)
• Similarity: 267/535 - (49%)
• Gaps: 83/535 - (15%)

  Fly    15 LYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEPKE 79
            |:.||:..|||.:|||.:..|::.|.||:.|:.||.:|.|.:.:||.:|:|..|.||:|||..:.
Zfish    30 LHRDLMVGYNKNIRPVESHEDIIDVKIKMTLTNLISLNEKEETLTTCVWIEMQWRDYRLRWANRT 94

  Fly    80 ----YGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDV 140
                |..:..:.:||..||.|||.|.||.||.|||.|.....|..:|.|.|.|||||:|||.|.|
Zfish    95 GFEVYENITRMRLPSKTIWLPDIGLENNVDGRFEVALYANTLIDPDGSVYWLPPAIYRSSCAIKV 159

  Fly   141 EYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVA--VGVDLSEFYMSVEWDILEVPA--V 201
            .|||||.|.|.:.|.|.||:..::.|...||   .||..  :.:|...|..:.||.|...||  |
Zfish   160 NYFPFDWQNCSMVFRSQTYNSNEITLMLSDE---DNVTMEWIEIDPEAFTENGEWMIKHRPAKKV 221

  Fly   202 RNEKFYTCCDE-PYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDS-GEKVTLSIS 264
            .|:::..  || .:.:|.|.:.::||.|||.:|||:||:..|.|.:|.::||:.: |:|.|::|.
Zfish   222 INKRYRP--DELEHQEIIFFLIIQRKPLFYVINIIVPCVLFSSLGLLVYFLPAKAGGQKCTMTIC 284

  Fly   265 ILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVK 329
            ||:...||..|:.:.:|.||..|||:||||:|.|.:.:|::...||||||..|:|.||.|:..::
Zfish   285 ILLGQTVFLFLIAKKVPETSQAVPLIGKYLMFVMSVTTITVMNCVVVLNVSLRTPNTHPMSNTIR 349

  Fly   330 RVFIDFLPAFLFIKRPTYNFETSK-----------------------LLLKDTHACFYPYYSATN 371
            :|.::.||..|.:....:..|..:                       |:.|.....|....|...
Zfish   350 KVLLNILPRVLRMTMQRWTPEQEEGDFKMFALGNGTPLRRRRRSSLGLIAKADEYMFRTARSELM 414

  Fly   372 IDRLVSSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSP 436
            ..||..   ...|.|..|.:  ..||..|.:.|.       ..||.  .||.|::
Zfish   415 FSRLKE---RKGLLKNTLEK--IQNGLGGNTAQD-------LECSL--AAASPEV---------- 455

  Fly   437 ILNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVG 501
                     .:|:    .||   :.|||.||.|.|.....|:|..||.|:||:..::..|..::|
Zfish   456 ---------QQCV----SSC---KHIAESTKHQNDFQSKNEEWFLVARVIDRMCFFVMALLFILG 504

  Fly   502 TAGIIL-----QAPT 511
            |.||.|     |||:
Zfish   505 TIGIFLTGHFNQAPS 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	179/522 (34%)
		Neur_chan_LBD	12..227	CDD:280998	89/220 (40%)
		Neur_chan_memb	234..505	CDD:280999	85/294 (29%)
chrng	NP_001241879.1	LIC	21..511	CDD:273305	181/525 (34%)
		Neur_chan_LBD	27..246	CDD:280998	89/220 (40%)
		Neur_chan_memb	253..509	CDD:280999	86/295 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810