Protein Alignment nAChRalpha4 and chrne

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_002941867.4
• Gene: chrne / 100497712
• XenbaseID: XB-GENE-979686
• Length: 505
• Species: Xenopus tropicalis
• Alignment Length: 525
• Identity: 182/525 - (34%)
• Similarity: 276/525 - (52%)
• Gaps: 63/525 - (12%)

  Fly     1 MVHGAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVE 65
            ::|.::|...:..||...|.:||:...||.....||:.|.:||.|:.|||:|.|.:.:|||:||:
 Frog    13 LLHNSLANESEESRLIKYLFTNYDSKARPSKGIDDVVPVSLKLTLTNLIDLNEKEETLTTNVWVQ 77

  Fly    66 QSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPA 130
            .:|.|.:|.|...||||:.::.||.|.:|.|:|||.||.||||||.......::|.|.:.|.|||
 Frog    78 IAWQDDRLTWNETEYGGMPLVQVPHDMMWLPEIVLENNIDGNFEVAYYANVLVHSTGYIYWLPPA 142

  Fly   131 IYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHM--DEQQGSNVVAVGVDLSEFYMSVEW 193
            |::|:|.|::.|||||.|.|.|.|.|.||....:|| |:  |::.|.....|.:|...|..:.||
 Frog   143 IFRSTCSIEITYFPFDWQNCSLVFRSKTYSANDIDL-HLVADDETGLPFDQVDIDREAFTENGEW 206

  Fly   194 DILEVPA--VRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDS- 255
            .|:..||  :.|.| |:..|..|.:|.|.:.::||.|||.:|||:||:.||.|.||.::||:.:
 Frog   207 AIMHRPARKIVNPK-YSKEDLRYQEIVFILIIQRKPLFYIINIIVPCVLISSLVVLVYFLPAKAG 270

  Fly   256 GEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQ 320
            |:|.|:|||:|::..||..|:.::||.|||.|||:||||:|.|.:.::.:...|:||||..|||.
 Frog   271 GQKCTVSISVLLAQTVFLFLIAQMIPETSLSVPLIGKYLMFVMFVSTLIVLSCVIVLNVSLRSPS 335

  Fly   321 THKMAPWVKRVFIDFLPAFLFIK-RPTYNFETSK---------LLLKDTHACFYPYYSATNIDRL 375
            ||.::..||.:.::.||.|:.:: .|....|.:.         ::||
 Frog   336 THTLSSKVKHMLLEVLPQFIHLRVEPCDEGEETPRERRRSSLGIMLK------------------ 382

  Fly   376 VSSGYNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPD---MDIGPLGMKSPI 437
             :..|....|:.:|.        |....:.||            :...||   .|...:|:.:.:
 Frog   383 -AEEYVLKKPRSELM--------FERQRERHG------------MRREPDGYRADGFDVGVTTTL 426

  Fly   438 LNNPAFSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGT 502
            ..|.|    :|.|:|........||.::||....:....|:|..:..|||.|..|:.....|:||
 Frog   427 YRNLA----QCAPEIKDCVDACNFITQNTKDDNATGAEMENWVLIGKVLDVLCFWVALPLFVLGT 487

  Fly   503 AGIIL 507
            ..|.|
 Frog   488 LAIFL 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	180/521 (35%)
		Neur_chan_LBD	12..227	CDD:280998	90/218 (41%)
		Neur_chan_memb	234..505	CDD:280999	83/284 (29%)
chrne	XP_002941867.4	LGIC_ECD_nAChR_G	47..241	CDD:349830	83/195 (43%)
		Neur_chan_memb	248..491	CDD:397193	83/285 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910