Protein Alignment nAChRalpha4 and chrna2

DIOPT Version :10

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_004914998.2
• Gene: chrna2 / 100495873
• XenbaseID: XB-GENE-1013893
• Length: 510
• Species: Xenopus tropicalis
• Alignment Length: 520
• Identity: 238/520 - (45%)
• Similarity: 318/520 - (61%)
• Gaps: 75/520 - (14%)

  Fly    13 KRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEP 77
            :||:..|.:.||:..|||.||:||:.|...|.::|||||:.|||:||||:|::|.|.||||||.|
 Frog    33 ERLFKRLFTGYNRWSRPVPNTSDVVIVKFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWNP 97

  Fly    78 KEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEY 142
            .:|..|..:.|||:.||.|||||||||||.|.:|..|||.::..|.|:|.|||||||||.|||.:
 Frog    98 ADYDNVTSIRVPSEMIWIPDIVLYNNADGEFAITHMTKAHLFHNGKVKWVPPAIYKSSCSIDVTF 162

  Fly   143 FPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKFY 207
            ||||:|:|.:||||||||...:||..|:.         .|||.:::.|.||.|:......|.|.|
 Frog   163 FPFDQQSCKMKFGSWTYDKAWLDLESMER---------NVDLKDYWESGEWAIVNAVGKYNSKKY 218

  Fly   208 TCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLHVF 272
            .||.|.|.|||:...:||..||||:|:||||:.||.||||.||||||.|||:||.||:|:||.||
 Frog   219 DCCTEIYPDITYYFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVF 283

  Fly   273 FLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDFLP 337
            .||:.||||.||||:||:|:||:|.||.|::||.:||.|||||.|||.||||..||:.||:|.:|
 Frog   284 LLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHKMPLWVRSVFLDHIP 348

  Fly   338 AFLFIKRP-------TYNFETSKLLLKDTHACFYPYYSATNID---------------RLVSSGY 380
            .:||:|||       ...::..:|.|..:     .|:..|::|               |.::: :
 Frog   349 RWLFMKRPPAPVEEVVSQYDAPELKLSTS-----KYWMETDVDDKWAEPEAELQTCHVRHMTT-H 407

  Fly   381 NNSLP-KEDLSQSITANGPFGGSCQV--HGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPA 442
            |.||. :.|.:..::     ||..|.  |         ||.|.|            :|..|.:|
 Frog   408 NQSLQYRYDYNHHVS-----GGQSQTPRH---------SSTETA------------ESSFLLSP- 445

  Fly   443 FSHSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIIL 507
             |..|.|..:|       :||.|.:.::....|||||||||||:||:|||:|.:..::||.|:.|
 Frog   446 -SVLKALEGVH-------YIANHLRAEDADFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 502

  Fly   508  507
             Frog   503  502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:455710	236/516 (46%)
		LGIC_ECD_nAChR_proto_alpha-like	11..229	CDD:349832	110/215 (51%)
		Cys-loop	136..150	CDD:349832	9/13 (69%)
chrna2	XP_004914998.2	LIC	9..503	CDD:455710	238/520 (46%)
		LGIC_ECD_nAChR_A2	32..238	CDD:349816	110/213 (52%)
		Cys-loop	156..170	CDD:349816	9/13 (69%)