Protein Alignment nAChRalpha4 and chrna5

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_002937929.1
• Gene: chrna5 / 100379824
• XenbaseID: XB-GENE-5755296
• Length: 476
• Species: Xenopus tropicalis
• Alignment Length: 524
• Identity: 203/524 - (38%)
• Similarity: 291/524 - (55%)
• Gaps: 110/524 - (20%)

  Fly     1 MVHGA--------VAGNPDAKRLYDDLL--SNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKN 55
            ::|||        :|.:.|  ||:..|.  .:|.:.||||.:..|.:||...|.::||:||:.||
 Frog    32 ILHGACGISEPSYIAKSED--RLFKYLFQQQDYQRWVRPVEHLNDTVKVKFGLAITQLVDVDEKN 94

  Fly    56 QIMTTNLWVEQSWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYS 120
            |:||||:|::|.|.|.||||:|.|:.|:..:.||||.||.||||||:||||.||.:: |||.:..
 Frog    95 QLMTTNVWLKQEWVDVKLRWDPNEFAGITSIRVPSDSIWIPDIVLYDNADGRFEGSV-TKAVVRY 158

  Fly   121 EGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLS 185
            :|.:.|.|||.|||||.|||.:||||.|.|.:|||||||||.:||:...|..         ||..
 Frog   159 DGTINWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDYH---------VDKR 214

  Fly   186 EFYMSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFY 250
            :|:.:.||:|:.....:..:...||..||  ||::..::|..||||:.:||||:|:||||:|.||
 Frog   215 DFFDNGEWEIVNATGNKGNRTDGCCFYPY--ITYSFIIKRLPLFYTLFLIIPCIGLSFLTILVFY 277

  Fly   251 LPSDSGEKVTLSISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVH 315
            |||:.|||::|..|:|:||.||.|::.||||.:|.|:||:|:||:|.||.|::||.:||..:|:|
 Frog   278 LPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIVLTVFAINIH 342

  Fly   316 FRSPQTHK-MAPWVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSG 379
            .||..||. |||||:::|:..||               |||...:|           :||..:.
 Frog   343 NRSSATHNAMAPWVRKIFLHKLP---------------KLLCMRSH-----------VDRYFTR- 380

  Fly   380 YNNSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFS 444
                  |::..             :|.||     ..|.:.:.|..|
 Frog   381 ------KDETG-------------KVRGP-----ESSRNTLEAALD------------------- 402

  Fly   445 HSKCLPKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQA 509
                         .:|:|..|...:.:..:|.||||:||.||||:|||.|.|..|:|:  :.|..
 Frog   403 -------------SIRYITRHVMKEHEVQEVVEDWKFVAQVLDRMFLWTFLLVSVIGS--LFLFI 452

  Fly   510 PTLY 513
            |.::
 Frog   453 PVIH 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	201/514 (39%)
		Neur_chan_LBD	12..227	CDD:280998	99/216 (46%)
		Neur_chan_memb	234..505	CDD:280999	93/271 (34%)
chrna5	XP_002937929.1	LIC	19..453	CDD:273305	202/519 (39%)
		LGIC_ECD_nAChR_A5	47..255	CDD:349819	100/221 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2037
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010