Protein Alignment nAChRalpha4 and chrna1

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_002934647.1
• Gene: chrna1 / 100145177
• XenbaseID: XB-GENE-977139
• Length: 457
• Species: Xenopus tropicalis
• Alignment Length: 506
• Identity: 201/506 - (39%)
• Similarity: 285/506 - (56%)
• Gaps: 84/506 - (16%)

  Fly     6 VAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYD 70
            |..:.|..||.:||..:|||:||||....|.:.|.:.|:|.|||:|:..|||:|||:.::|.|.|
 Frog    18 VFSSEDESRLINDLFKSYNKVVRPVKAFKDKVVVTLGLQLIQLINVDEVNQIVTTNVRLKQQWED 82

  Fly    71 YKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSS 135
            ..|:|.|::|||:..:.:.|..||||||||||||||:|.:...||..:...|.:.|.||||:||.
 Frog    83 VHLKWNPEDYGGIKKVRISSGDIWRPDIVLYNNADGDFAIVQETKVLLDYTGKIIWTPPAIFKSY 147

  Fly   136 CEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPA 200
            ||:.|.|||||.|.|.:|.|:|||||..|.:....::.         |||.|..|.||.:.:...
 Frog   148 CEMIVTYFPFDLQNCSMKLGTWTYDGSLVVINPESDRP---------DLSNFMESGEWYMKDYRG 203

  Fly   201 VRNEKFYTCCDE-PYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSIS 264
            .::..:|.||.| ||||||::..::|..|::.||::|||:..||||.|.||||:|||||:|||:|
 Frog   204 WKHWVYYDCCPETPYLDITYHFLLQRLPLYFIVNVVIPCLLFSFLTGLVFYLPTDSGEKITLSVS 268

  Fly   265 ILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVK 329
            :|:||.||.|::||:||.||..|||:|||::|.|:.|..||.:||:|:|.|.|||.||.|..|:|
 Frog   269 VLLSLVVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVITSIVITVIVINTHHRSPSTHIMPQWLK 333

  Fly   330 RVFIDFLPAFLF---IKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQ 391
            ::||:.:|..:|   :|||..:.:..|:..:|             ||....||
 Frog   334 KIFIETIPRVMFFSTMKRPAQDQQKKKIFTED-------------IDISDISG------------ 373

  Fly   392 SITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMK--SPILNNPAFSHSKCLPKIHK 454
                                               .:||..:|  ||||.|         |.:..
 Frog   374 -----------------------------------KLGPAAVKYQSPILKN---------PDVKS 394

  Fly   455 SCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGI 505
            :....::|||..|..::|.|..|:||:||||||.|.|.:|.:..::||..|
 Frog   395 AIEGAKYIAETMKSDQESNKASEEWKFVAMVLDHLLLAVFMIVCIIGTLAI 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	200/504 (40%)
		Neur_chan_LBD	12..227	CDD:280998	96/215 (45%)
		Neur_chan_memb	234..505	CDD:280999	99/275 (36%)
chrna1	XP_002934647.1	LIC	21..447	CDD:273305	200/503 (40%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	97/217 (45%)
		Cys-loop	148..162	CDD:349815	9/13 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110