Protein Alignment nAChRalpha4 and chrnb1l

DIOPT Version :9

• Sequence 1: NP_001097669.2
• Gene: nAChRalpha4 / 40521
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001233249.1
• Gene: chrnb1l / 100005295
• ZFINID: ZDB-GENE-060811-1
• Length: 486
• Species: Danio rerio
• Alignment Length: 537
• Identity: 190/537 - (35%)
• Similarity: 289/537 - (53%)
• Gaps: 80/537 - (14%)

  Fly     2 VHGAVAGNPDAKRLYDDLLSNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQ 66
            ::|:...:...:||.:||..:||..|||.....:.:.|.:.:.|.|||.:|.||..||||:::..
Zfish    10 INGSRKASEAERRLLEDLFQDYNLKVRPARTWNERVMVRVGMTLVQLISLNQKNGEMTTNVFMNM 74

  Fly    67 SWYDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAI 131
            .|.||:|.|.|::|..:.::.:|...:|||||.|.||.||.|:|.|.....:.|:|.|.|.||||
Zfish    75 EWTDYRLSWNPEDYDKIDVVRIPPVKVWRPDIYLINNNDGQFDVALYVNVLVRSDGTVSWLPPAI 139

  Fly   132 YKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDIL 196
            |:|||.|:|.|||||.|.|.:.|.|:|||..:|||::..::.|:.:..:.:|.:.|..:.||.|.
Zfish   140 YRSSCSIEVAYFPFDWQNCSMVFRSYTYDSSEVDLQYGLDEDGNELHEIVIDENAFTENGEWQIC 204

  Fly   197 EVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTL 261
            ..|:.:|.:     |:.|.||||.:.:.||.|||.:|||:||:..|.|.:..||||..:|||:||
Zfish   205 HKPSRKNVQ-----DDLYEDITFYLIIERKPLFYVINIIVPCILTSVLAIFVFYLPPGAGEKMTL 264

  Fly   262 SISILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAP 326
            |||:||:|.||.||:.:.:|.|||.:|::..|::|.||||:.|:.::|||||:|.|:|.||.|..
Zfish   265 SISVLIALTVFMLLLADKVPETSLAIPIIVNYVMFTMILVTFSVILSVVVLNLHHRTPSTHHMPG 329

  Fly   327 WVKRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQ 391
            ||::|||:.||.:|.:.|||                                      |:|.:.:
Zfish   330 WVRKVFINLLPRYLGVLRPT--------------------------------------PEEPVEE 356

  Fly   392 SITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNP-------------AF 443
            ....|.|.|              |..:.:....:..|..:   :|.|..|             .|
Zfish   357 EPKENVPMG--------------CLGNSLRPGGEYFIRKI---NPELVMPWRGSHNESTVKLQRF 404

  Fly   444 SHSK--CL---PKIHKSCFCVRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTA 503
            |:|.  ||   |.:..:...:.:::|..|.|:....:.:||:|:|:||||||||:|.:...:||.
Zfish   405 SNSDNYCLILPPNLKSAIAAITYMSEQLKKQDVDDTMTDDWQYIAVVLDRLFLWLFVVITTLGTL 469

  Fly   504 GIILQAPTLY--DDRIP 518
            .:.|.|...|  |...|
Zfish   470 TMFLDASFNYTPDQPFP 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	185/520 (36%)
		Neur_chan_LBD	12..227	CDD:280998	86/214 (40%)
		Neur_chan_memb	234..505	CDD:280999	93/288 (32%)
chrnb1l	NP_001233249.1	LIC	11..473	CDD:273305	185/521 (36%)
		Neur_chan_LBD	20..230	CDD:280998	86/214 (40%)
		Neur_chan_memb	237..472	CDD:280999	93/289 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910