DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha4 and chrnb5a

DIOPT Version :9

Sequence 1:NP_001097669.2 Gene:nAChRalpha4 / 40521 FlyBaseID:FBgn0266347 Length:539 Species:Drosophila melanogaster
Sequence 2:XP_009289434.1 Gene:chrnb5a / 100003503 ZFINID:ZDB-GENE-090312-169 Length:494 Species:Danio rerio


Alignment Length:517 Identity:230/517 - (44%)
Similarity:307/517 - (59%) Gaps:54/517 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 KRLYDDLL--SNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRW 75
            :||.|.||  ..||||:||.||.:..:.:.||:.|:|||.||.:.||||||:|:.|.|.||:|.|
Zfish    30 ERLVDFLLGPERYNKLIRPAVNKSQQVTIGIKVSLAQLISVNEREQIMTTNVWLTQEWNDYRLVW 94

  Fly    76 EPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEIDV 140
            :|.||.|:..|.:||.|||.|||||||||||.:||:....|.:.:.|.:.|.|||||||:|.|:|
Zfish    95 DPNEYEGIKKLRIPSRHIWLPDIVLYNNADGVYEVSFYCNAVVSNTGDIFWLPPAIYKSACAIEV 159

  Fly   141 EYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEK 205
            ..||||:|.|.|||.|||||..::|| ::.....|.        .::..|.||||:.:|..|||.
Zfish   160 RNFPFDQQNCTLKFRSWTYDRTELDL-YLTSDFASR--------DDYTPSGEWDIVSLPGRRNED 215

  Fly   206 FYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILISLH 270
            .   .|..|||:|::..::||.||||:|:||||:.|:.|.:|.||||||.|||:||.||:|::|.
Zfish   216 L---SDPTYLDVTYDFVIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALT 277

  Fly   271 VFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWVKRVFIDF 335
            ||.||:.:|:|||||.|||:||||:|.|:||:.||..:|.|||||.|||.||:|..||||||:..
Zfish   278 VFLLLISKIVPPTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHRMPEWVKRVFLHK 342

  Fly   336 LPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSITANGPFG 400
            ||.||.::||..:....:...|.....|   .|.|...||....|            ..::.|  
Zfish   343 LPFFLLMRRPGRSNVRERFRRKHQRKSF---SSDTKGLRLDGDSY------------FLSDDP-- 390

  Fly   401 GSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFCVRFIAEH 465
                  |.|     |.:..:..:|:        .|.........|.   |.:.::...|||||||
Zfish   391 ------GRV-----CGAWRVGDLPE--------GSEFRQRVKVRHD---PDVDEAIEGVRFIAEH 433

  Fly   466 TKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYDDRIPIIEQKDLDF 527
            .|:::|...:.|||||||||:||||||||.|..||||.|:.:| |.......|:.|::..||
Zfish   434 MKIEDDDEGIIEDWKYVAMVIDRLFLWIFILVCVVGTLGLFVQ-PLFQSYNTPVAEEEYGDF 494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha4NP_001097669.2 LIC 1..505 CDD:273305 223/493 (45%)
Neur_chan_LBD 12..227 CDD:280998 102/215 (47%)
Neur_chan_memb 234..505 CDD:280999 115/270 (43%)
chrnb5aXP_009289434.1 Neur_chan_LBD 20..474 CDD:332142 224/494 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm24622
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.920

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