Protein Alignment LTBP1 and ltbp1

DIOPT Version :10

• Sequence 1: XP_011531155.1
• Gene: LTBP1 / 4052
• HGNCID: 6714
• Length: 1722
• Species: Homo sapiens
• Sequence 2: XP_017207300.2
• Gene: ltbp1 / 562072
• ZFINID: ZDB-GENE-091202-8
• Length: 1527
• Species: Danio rerio
• Alignment Length: 1781
• Identity: 828/1781 - (46%)
• Similarity: 1040/1781 - (58%)
• Gaps: 342/1781 - (19%)

Human     4 AWLRWGLLLWAGLLASSA-----HGRLRRITYVVHPGP----GLAAGALP----LSGPPRSRTFN 55
            |.|.|.:::...||.|.|     ....|:: |||.|||    |:...::.    .||.|.|  :|
Zfish     2 AMLVWDIIVSVTLLISPAFLSADQSGFRKL-YVVQPGPSGTDGVHVSSISSLSGASGQPHS--YN 63

Human    56 VALNARYSRSSAAAGAPSRASPGVPSERTRRTSKPGGAALQGLRPPPPPPPEPARPAVPGGQLHP 120
            |.|.|.:                                                    |||:..
Zfish    64 VELKASF----------------------------------------------------GGQVRT 76

Human   121 NPGGHPAAAPFTKQGRQVVRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGRCCHGWSKAPGSQR 185
            ...||          :|.....:.|:.|||   |.......::.|||||||:||.||||.|||||
Zfish    77 RRMGH----------QQNPSIPIRQDAQSG---RHTSSHHMKVSGVNVCGGQCCVGWSKTPGSQR 128

Human   186 CTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACETIAAQDTSSPV--FGGQSPGAASSWGPPEQA 248
            ||||:|.|||:||||||.|.:||||||:|||:||......:|.|.  ..|.:.|...:.|
Zfish   129 CTKPNCTPPCKNGGMCLGPHMCVCKPGSKGKSCEQTTLPPSSHPTGPLNGHTNGGVPNGG----- 188

Human   249 AKHTS--SKKADTLPRVSPVAQMT-------------------LTLKPKPSVGLPQQIHSQV-TP 291
              ||:  |...:.:|: .|:.|..                   |||..||||..|.....|: .|
Zfish   189 --HTNGYSNGHNVIPQ-RPIPQQIFPQGQGQVPLPLPGTNVGHLTLSMKPSVNGPIPYQPQIQNP 250

Human   292 LSSQSVVIHHGQTQEYVLKPKYFPAQKGISGEQST-EGSFPLRYVQDQVAAPFQLSNHTGRIKVV 355
            :   |:.:|..::|:::::.|.:.....:.|...| ..:.||....:    |..:.|||||||||
Zfish   251 V---SMTMHQSKSQKFLVQQKNYHTHTQMQGVGPTLNRAIPLSVGHN----PIHVGNHTGRIKVV 308

Human   356 FTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQ 420
            |||:|||:|||.|.|||||:||||||:|||||||.|||||.|||||:|||||||||:||:|||||
Zfish   309 FTPTICKMTCTNGRCQNSCQKGNTTTIISENGHATDTLTAPNFRVVVCHLPCMNGGKCSTRDKCQ 373

Human   421 CPPNFTGKLCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNI 485
            ||||||||.||:     :.|..:|..........||| |||||||||..:.|.      ..:||:
Zfish   374 CPPNFTGKFCQM-----ASPNGHQGQHTVVNGQKTHV-HSTHTLPLTYGTGQN------QGMVNV 426

Human   486 HVKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTI-----HS--TYSHQQV 543
            ||||||||||||||||.:|. .|| .|..|...| .:|.    ..:|:|     ||  .|.:||.
Zfish   427 HVKHPPEASVQIHQVSPVDS-NGQ-VKNTQSSHS-FTYH----SSSQSIQHGHTHSGVIYPNQQT 484

Human   544 IPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQ 608
            .....||.:|:|||||||||.|.||||||||||||:.|||||||||||:||||||||||.    .
Zfish   485 YLQYQPVTSKSQLGRCFQETTGMQCGKALPGLSKQDACCGTVGTSWGFHKCQKCPKKPSI----P 545

Human   609 MMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVIS 673
            ::||..||||:|.|.|.||:|||||||||||.|:||:|||||.|..||.|||:.:||.|:.|.:.
Zfish   546 LIECPQGYKRLNGTRCIDIDECQLQGVCPNGNCINTVGSYRCICNPGFVPDPSLTSCFPETPALR 610

Human   674 EEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVS 738
            ||||.|:|.|.||:||:||:|..|:||||||||||||||||::||||||||||:||||||||.|:
Zfish   611 EEKGACFRFVGSGKQCLHPVSTQLSKQLCCCSVGKAWGPHCDRCPLPGTAAFKDICPGGMGYHVT 675

Human   739 G--VHRRRPIHHHV---GKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPE 798
            .  :::.:|.:.|.   |:|  :..|.....|.... |.|.|..::|||||:.:
Zfish   676 PPYIYKPKPPNGHTQTDGQG--YNNPTIRHQVPMDP-PVPFPTLQQPVEALSIT----------- 726

Human   799 VATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQFPGIVIEKTSPPVPVEVAPEASTSSA 863
                  |:::|.                               |:||.|||.||.:.|    |:.
Zfish   727 ------ERQLPE-------------------------------VVEKVSPPAPVAIPP----SNE 750

Human   864 SQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCS 928
            .|.|.|||:.||:||.|.|||||||.|.|....|||.|.:|||...:...|||:|||.:...||:
Zfish   751 GQDITPTQLAEIDECVVRPDICGAGICYNTAESYTCFCDDGYRTDSEGTTCVDVDECAENPSLCA 815

Human   929 QGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQ 993
            .|||:||.|.|||:|..|||.:|.|::
Zfish   816 NGRCQNTPGGFLCVCELGFMPNERGSS-------------------------------------- 842

Human   994 RGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLE 1058
               |.|||||.|...||...|.|:.||:.|.||.:||.|.||||:|::|||:..|||:|.|||||
Zfish   843 ---CSDIDECQNRRACPSGLCYNTLGSFMCSPCPDGFEGKNGQCVDINECLDERVCAHGQCSNLE 904

Human  1059 GSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDID 1123
            |.::|:|.:|:..|||.|.|.||||||..|:|:.|.|:||:|||.|.|..|::||::.|||||:|
Zfish   905 GYFVCTCDEGFLPTPDGKSCTDIDECQDDNVCIQGHCQNTQGSFICNCEPGFKLSSSGDQCEDVD 969

Human  1124 ECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCT 1188
            ||                   .|..|         .|:.:            |.|:|..|||.|.
Zfish   970 EC-------------------LVIPQ---------TCDGV------------GQCVNILGSYQCN 994

Human  1189 CPDGFQLDDNKTCQDINECE-HPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VN 1251
            ||.|::..::.:|.|::||| ...||.|.||||||||||.|||..||..:..|  |:|:||| :|
Zfish   995 CPQGYRQVNSTSCLDVDECEDDTQLCIPNGECLNTEGSFLCVCDAGFVSTRTG--CQDVDECSLN 1057

Human  1252 NTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCAD 1316
            ...|.|||.|.||.|||.|.|..||:..|||||||||||||||..|||||.|||.||:|||:|.|
Zfish  1058 ENTCGSHGTCQNTIGSFICQCDPGFKDSQDGQGCVDVNECELLGNVCGEATCENREGTFLCLCPD 1122

Human  1317 ENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGW 1381
            :.||:.||.|:|   .||.....|     |:||||:||||.:|||.|||.::||:|||||.|.||
Zfish  1123 DLQEFDPMLGKC---ISTPPVTTV-----ERKECYFNLNDENLCDKVLASSMTKEECCCTLGAGW 1179

Human  1382 GDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGE--SSSEAGGENYK-DADECLLFGQEICKNGFCL 1443
            |||||:.|||:.||.:|::|||.|:|::.:|:  |::.:..||.| |||||.|||.||||:||||
Zfish  1180 GDNCEVHPCPIPGTDQFSQMCPAGRGYLISGDPMSTTSSLAENTKADADECQLFGSEICKDGFCL 1244

Human  1444 NTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCI 1508
            ||...||||||.|.|||..||||.|.|||||.:.|.||:|:||.|||.||||.||||......||
Zfish  1245 NTAGWYECYCKSGLYYDESKLQCLDTDECQDEAKCRDGECMNTYGSYQCFCTPPMVLAMDNTHCI 1309

Human  1509 RPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDD 1573
            .|..:.:  .|.|:|..:|||.:::.:.|:.|:....|::||||||||||||..|||||.|::|.
Zfish  1310 LPDVAGQ--SEADLYSGVCWERVTENFSCANPITNIHTSFTECCCLYGEAWGNDCALCPGKNTDS 1372

Human  1574 YAQLCNIPVTGRRQPYGRDALV--------DFS-------------EQYTPEADPYFIQDRFLNS 1617
            |||:|||     |:||||||||        |::             |.|....:||       ::
Zfish  1373 YAQMCNI-----RRPYGRDALVAGPIGVSPDYNPQPLNPDGMLPYIEDYDEPRNPY-------DA 1425

Human  1618 FEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKC 1682
            ||.|:|||||:||||||||||||||||||||||||.||.::|.|||:|||.|||.:||||||..|
Zfish  1426 FEGLRAEECGVLNGCENGRCVRVQEGYTCDCFDGYTLDMSRMACVDINECSELNAKMSLCKNGNC 1490

Human  1683 INTDGSYKCLCLPGYVPSDKPNYCTP 1708
            |||.|||||:||||::.|.:.|||.|
Zfish  1491 INTQGSYKCVCLPGFILSAQHNYCVP 1516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LTBP1	XP_011531155.1	TB	567..602	CDD:459903	31/34 (91%)
		EGF_CA	626..>656	CDD:214542	22/29 (76%)
		TB	688..729	CDD:459903	32/40 (80%)
		PHA03247	<742..869	CDD:223021	28/129 (22%)
		EGF_CA	916..957	CDD:214542	21/40 (53%)
		EGF_CA	958..998	CDD:214542	0/39 (0%)
		EGF_CA	999..1032	CDD:238011	17/32 (53%)
		EGF_CA	1039..1078	CDD:214542	21/38 (55%)
		EGF_CA	1080..1111	CDD:214542	18/30 (60%)
		EGF_CA	1121..1161	CDD:214542	6/39 (15%)
		EGF_CA	1162..1192	CDD:429571	9/29 (31%)
		EGF_CA	1203..1244	CDD:214542	23/41 (56%)
		EGF_CA	1245..1286	CDD:214542	24/41 (59%)
		TB	1360..1402	CDD:459903	26/41 (63%)
		TB	1536..1578	CDD:459903	25/41 (61%)
		EGF_CA	1663..>1697	CDD:214542	25/33 (76%)
ltbp1	XP_017207300.2	None