DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LTBP1 and nid-1

DIOPT Version :10

Sequence 1:XP_011531155.1 Gene:LTBP1 / 4052 HGNCID:6714 Length:1722 Species:Homo sapiens
Sequence 2:NP_001256465.1 Gene:nid-1 / 179770 WormBaseID:WBGene00003738 Length:1584 Species:Caenorhabditis elegans


Alignment Length:1644 Identity:318/1644 - (19%)
Similarity:489/1644 - (29%) Gaps:632/1644 - (38%)


- Green bases have known domain annotations that are detailed below.


Human   311 PKYFP-------AQKGISGEQSTEG-SFPLRYVQDQVAAPFQLSN-----------HTGRIKVVF 356
            |.::|       .:...|.|||... ..||.|::..|...|...|           ..|.:..:.
 Worm    23 PAFYPYGQPAGDNRLDYSMEQSAIALKIPLTYMEQSVDELFLSHNGIVGLGKPTPEKIGGLMTIS 87

Human   357 TPSIC--KVTCTKGSCQ---NSCEKGNTTTLISENGHA-ADTLTATNFRVVICHLPCMNGGQCSS 415
            ||:|.  .|..|.|...   :|.::|..|.|..:.... ||.:.....:.||     :...|..:
 Worm    88 TPAIAVFYVPVTSGVIDYRVSSDDQGLLTKLTQDVKQVFADAVEFHGLQAVI-----ITWTQIEN 147

Human   416 RDKCQCPPNFTGKLCQIPV--HGASVPKLYQHSQQP-GKALGTHV----IHSTHTLPLTVTSQQG 473
            .:| ..|.:|     |:.:  .|.|...::::...| ..::|.:.    :.|...:...|.| .|
 Worm   148 AEK-DGPASF-----QLAIVSDGISTYAIFRYESLPWSSSMGYYAQAGFVRSIGKIQTNVNS-GG 205

Human   474 VKVKFPPNIVNIHVKHPPEASVQIHQV--SRIDGPTGQKTKEAQPGQSQVSYQG-----LPVQK- 530
            ..||...|:.|...     .:..|.:|  |.|:.|..:...:.........|:|     .|..| 
 Worm   206 PDVKELVNLSNNQF-----GNFFIFRVSGSAIEDPKDEGADDYDYNNYDQEYEGEHPADCPKDKF 265

Human   531 -------TQTIHSTYSHQQVI----PHV--YPVAAKTQL--------------GRCFQETIGSQC 568
                   .:|:......::.|    ||.  .|...:.:|              |..::|      
 Worm   266 VDNCPAECRTVRDERGCERCICAERPHAPRAPQEPRPELENTVEDDEDDEQVDGTRYEE------ 324

Human   569 GKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKP------SYHGYNQMMECLPGYKRVNNTFCQDI 627
                |....||.          .::....|.:|      |..|....|.|..          :|.
 Worm   325 ----PARQAQEQ----------HHQQHHQPDQPQQQPQRSQEGSLPKMSCSQ----------RDD 365

Human   628 NECQLQGVCPNGECLNTMGSYRCTCKIGF---GPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQC 689
            ..|....||.:.|     |.:.|.|..||   |.:     |:|        ||...|:..|....
 Worm   366 KSCHANSVCQDFE-----GGFCCNCDTGFYGNGKE-----CLP--------KGEPQRISGSFEGV 412

Human   690 MHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMG------YTVSGV-------- 740
            ::.:.:..| :|...:.......|        ||..|  .|..:|      |::.||        
 Worm   413 INRIPIDKT-ELHTFATSTDGNVH--------TAVSK--IPSDLGHPLRFLYSIGGVMGWLFADV 466

Human   741 ----------------HRRRPIH------------------HHVGKGPVFVKPKNTQPVAKSTHP 771
                            :|...:|                  |...|..:||         ..|.|
 Worm   467 QSPNVYNGFQLTGGLFNRTVALHIEQNYYVTIKQEFSGRNIHDYFKSHLFV---------SGTLP 522

Human   772 PPLPAKEE--PVEALTFSREH----------------GPGVAEPEVATAPPEKEIPSLDQEKTKL 818
            ...|..|.  |.....:.||.                |..|....:          |:||:.|..
 Worm   523 DIAPGSEVIFPDYEEEYVRERRGYLTSKAAFDVIVRDGGNVQTYRM----------SVDQQITFE 577

Human   819 EPGQPQLSPGISTIHLHPQFPGIV----------------IEKTSPPV----------------- 850
            |....:.....| :.||.:...:|                .....|.|                 
 Worm   578 ECPNKEFDRDHS-MKLHVKRINVVYNDDEGVVRYGAKNFATRSVGPAVSAPSGGHFDRRQHGQSN 641

Human   851 -----PVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQ 910
                 |:|:..::.:.|...|.||.:    ::||: |::    .|..:...|.|.|..||:.:..
 Worm   642 MASERPIEIPSQSESISTDSVCAPGR----HQCTL-PNM----KCRVVDPSYRCECEPGYQAAHD 697

Human   911 QRK-----CVDIDECTQVQHLCSQ-GRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCG 969
            ...     |.|:|||.:..|.|.| .:|.|..|||.|.|..|:..  :|.:||...:....:   
 Worm   698 ASSHIGWICQDLDECQRGDHNCDQHAKCTNRPGSFSCQCLQGYQG--DGRSCIREHQASHHE--- 757

Human   970 EGHCVNT------VGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTE 1028
              |...|      |||....:|      |...:|....||:..|..|..:|       :|     
 Worm   758 --HNQQTPQEMAGVGATTEGFC------TAHNQCHQWGECVFTSEHPTGRC-------KC----- 802

Human  1029 GFRGW---NGQCLDVDECLEP---------NVCANGD--CSNLEGSYMCSCHKGYTRTPDHKHCR 1079
              |||   :|    |:.|..|         |:...|.  |    |||:|.               
 Worm   803 --RGWYVGDG----VNHCGPPEENMPKHNANIPQRGGQAC----GSYVCD--------------- 842

Human  1080 DIDECQQGNLCVNGQC-KNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSF 1143
                       ||.:| ....|...|.|..|:  |.....||.:.:.:|.| .:|.:        
 Worm   843 -----------VNAECMPEPSGGSECVCKAGF--SGNGVTCESLLDDRHAH-SSHNR-------- 885

Human  1144 QCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCI--NTAGSYDCTCPDGFQLDDNKTCQDINE 1206
               .:|..:...||..|...:||.|      .|.|.  ::.|.|.|.|.:.:             
 Worm   886 ---HEQQQQTGSLGKVCRSHDECSE------HGSCAYHHSLGYYQCACTEPY------------- 928

Human  1207 CEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCL 1271
                  .|...|| ...||.....:.|..::.|   |.:..:||...        .:|..:|||:
 Worm   929 ------VGNGVEC-TLPGSSASAPELGCDVTRD---CSEFADCVYER--------SSTGATFRCV 975

Human  1272 CYQGFQAPQDGQGCV-----------DVNECELLSGVCGEAFCE-NVEGSFLCVCADENQEYSPM 1324
            |..|:..  ||:.|:           .|.:......|...|.|. |......||..|.|::|   
 Worm   976 CQSGYTG--DGKYCMQSQLAISAISPSVPQLPSEPAVLSTASCNPNCGPDAQCVYDDHNRQY--- 1035

Human  1325 TGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGWGDNCEIFP 1389
              :|                    |||                        .:.:|.|.||    
 Worm  1036 --RC--------------------ECY------------------------AAFMGDGYNC---- 1050

Human  1390 CPVLGTAEFTEMCPKGK-GFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPG---YE 1450
                        .|..| ..|||...:.       .::.:|.:       ||.|:....|   |.
 Worm  1051 ------------VPLAKPNMVPAQPKTC-------VESSDCHI-------NGHCVINEHGAGEYI 1089

Human  1451 CYCKQGTYYDPVKLQCFDMDEC--QDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCI----- 1508
            |.|..|...|.. :.|...|:|  .:||:|..          |..|.:..:|:|...:|:     
 Worm  1090 CQCLPGFSGDGF-INCRGADQCNPSNPSACYQ----------NAHCVYDAILNAHACKCVDGFKG 1143

Human  1509 --------RPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCAL 1565
                    .|| :|..:|..     :|  |.:.:                 |.::.:....:|..
 Worm  1144 DGTSCVPYAPA-TNCNLEPR-----IC--HANAQ-----------------CVMHHDTNAYECIC 1183

Human  1566 CPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILN 1630
            .|....|.|.: |::..|.|                                     ...|.|..
 Worm  1184 KPGSSGDGYTK-CDVIETPR-------------------------------------CTNCSIHA 1210

Human  1631 GCENGRCVRVQEGYTCDCFDGY----HLDTAKMTCVDVNECDELNNRMSLC-KNAKCINTD-GSY 1689
            .|...   .....|.|.|..||    ||      ||.::.|  |::| ||| :||.|:..: |.|
 Worm  1211 YCAQN---PTSGAYQCKCNAGYNGNGHL------CVSMSSC--LDDR-SLCDENADCVPGEAGHY 1263

Human  1690 KCLCLPGYVPSDKPNYCTP 1708
            .|.|..||....:.  |:|
 Worm  1264 VCNCHYGYHGDGRS--CSP 1280

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LTBP1XP_011531155.1 TB 567..602 CDD:459903 5/40 (13%)
EGF_CA 626..>656 CDD:214542 8/29 (28%)
TB 688..729 CDD:459903 6/40 (15%)
PHA03247 <742..869 CDD:223021 30/200 (15%)
EGF_CA 916..957 CDD:214542 16/41 (39%)
EGF_CA 958..998 CDD:214542 7/45 (16%)
EGF_CA 999..1032 CDD:238011 6/32 (19%)
EGF_CA 1039..1078 CDD:214542 10/49 (20%)
EGF_CA 1080..1111 CDD:214542 7/31 (23%)
EGF_CA 1121..1161 CDD:214542 6/39 (15%)
EGF_CA 1162..1192 CDD:429571 9/31 (29%)
EGF_CA 1203..1244 CDD:214542 7/40 (18%)
EGF_CA 1245..1286 CDD:214542 10/40 (25%)
TB 1360..1402 CDD:459903 4/41 (10%)
TB 1536..1578 CDD:459903 5/41 (12%)
EGF_CA 1663..>1697 CDD:214542 13/35 (37%)
nid-1NP_001256465.1 NIDO 93..232 CDD:214712 31/155 (20%)
EGF_3 368..396 CDD:463759 10/37 (27%)
G2F 398..629 CDD:214774 42/269 (16%)
EGF_3 712..747 CDD:463759 13/36 (36%)
EGF_3 841..870 CDD:463759 9/56 (16%)
EGF_3 952..987 CDD:463759 12/47 (26%)
EGF_3 1205..1236 CDD:463759 10/39 (26%)
EGF_3 1242..1278 CDD:463759 15/40 (38%)
NHL <1319..1513 CDD:302697
NHL repeat 1319..1354 CDD:271320
NHL repeat 1362..1399 CDD:271320
NHL repeat 1402..1445 CDD:271320
NHL repeat 1450..1482 CDD:271320
NHL repeat 1490..1513 CDD:271320
FXa_inhibition 1553..>1577 CDD:464251
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.